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ChemicalBook > Product Catalogue >API >Respiratory Drugs >Asthma drugs >Aminophylline

Aminophylline

Aminophylline Structure
  • ₹0
  • Product name: Aminophylline
  • CAS: 317-34-0
  • MF: C9H16N6O2
  • MW: 240.27
  • EINECS:206-264-5
  • MDL Number:MFCD00013221
  • Synonyms:AMinophyllin Anhydrous USP;3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione;Aminophylline dihydrochloride hyderate;Aminophylline, >=98%;(Theophylline)2 · Ethylenediamine 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, cmpd. with 1,2-ethanediamine (2:1) Theophylline hemiethylenediamine complex Theophylline, compound with ethylenediamine (2 to 1) dihydrate Theophylli;3,7-dihydro-1,3-dimethyl-1h-purine-2,6-dionecompd.with1,2-ethanediamine(2 ;aminocadol ;aminodur
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :269-270 °C
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :H2O: 3.7 mg/mL solutions should be freshly prepared.
form :powder
pka :pKa 5.0 (Uncertain)
color :white to off-white
Water Solubility :soluble
Merck :14,465
InChI :InChI=1S/C7H8N4O2.C2H8N2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h3H,1-2H3,(H,8,9);1-4H2
InChIKey :LHRHXWBJUQKYEL-UHFFFAOYSA-N
SMILES :O=C1N(C(=O)N(C)C2NC=NC1=2)C.C(N)CN
LogP :-0.175 (est)
CAS DataBase Reference :317-34-0(CAS DataBase Reference)
EPA Substance Registry System :1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1) (317-34-0)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

Aminophylline is a drug combination consisting of bronchodilator theophylline and ethylenediamine in 2: 1 ratio. It is a kind of non-selective adenosine receptor blocker, histone deacetylase activator and phosphodiesterase inhibition. It is mainly indicated for the treatment of various kinds of lung diseases including asthma, COPD, chronic bronchitis and emphysema. Aminophylline exerts its effect through the component of theophylline in vivo. Theophylline can relax the smooth muscle of the bronchial airways and pulmonary blood vessels. It can competitively inhibits type III and type IV phosphodiesterase (PDE), which breaks down cyclic AMP in smooth muscle cells, possibly leading to bronchodilation. Theophylline also binds to the adenosine A2B receptor to block the adenosine mediated bronchoconstriction. Furthermore, during the inflammatory states, theophylline can activate the histone deacetylase to prevent transcription of inflammatory genes that require the acetylation of histones to initiate the transcription.

More related product prices

110-18-9 Theophylline 2,6-Dimethyl-7-octen-2-ol Dimethyl sulfoxide Dimethyl fumarate Purine 2-(2-Aminoethylamino)ethanol Dimethyl phthalate 333-18-6 1465-25-4 Dimethyl ether ETHANE Ethylenediamine Ammonia Aminophylline

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Suppliers and manufacturers

Aarti Industries Limited (AIL) Bajaj Healthcare Ltd S S Pharmachem Bakul Pharma Private Limited KPS Chemicals And Pharmaceuticals AKASH PHARMA EXPORTS OCEAN TRADING CORPORATION TCI Chemicals (India) Pvt. Ltd. Pharmaffiliates Analytics and Synthetics P. Ltd Aquatic Remedies Private Limited