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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Metabolism >PDE inhibitors >Apremilast

Apremilast

Apremilast Structure
  • ₹0
  • Product name: Apremilast
  • CAS: 608141-41-9
  • MF: C22H24N2O7S
  • MW: 460.5
  • EINECS:807-237-6
  • MDL Number:MFCD18782607
  • Synonyms:(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide;ApreMilast,CC-10004;AcetaMide, N-[2-[(1S)-1-(3-ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide Apremilast (CC-10004;(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl);Apremilast (S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione;Appleton West;N-[2-[(1S)-1-(3ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :152-156°C
Boiling point :741.3±60.0 °C(Predicted)
Density :1.381
storage temp. :Refrigerator
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
pka :14.01±0.20(Predicted)
form :Solid
color :White to Pale Yellow
InChIKey :IMOZEMNVLZVGJZ-QGZVFWFLSA-N
SMILES :C(NC1=CC=CC2=C1C(=O)N([C@@H](C1=CC=C(OC)C(OCC)=C1)CS(C)(=O)=O)C2=O)(=O)C
CAS DataBase Reference :608141-41-9

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P281 Use personal protective equipment as required.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Apremilast (Otezla) was approved by the FDA on March 21, 2014 for the treatment of adult patients with active psoriatic arthritis. Apremilast is a member of a new class of oral small molecule inhibitors of the phosphosphodiesterase 4 (PDE4) enzyme. When PDE4 is inhibited in immune cells, it results in elevation of intracellular cyclic adenosine monophosphate (cAMP) levels, which can regulate inflammatory mediators. The current clinical data indicate that apremilast is an effective and well tolerated option for the management of psoriasis and PsA in adults.

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Suppliers and manufacturers

Jigs Chemical ltd Saptagir Laboratories PVT.LTD. Anant Pharmaceuticals Pvt Ltd Bulat Pharmaceutical Pvt Ltd GLP Pharma Standards Lewens Labs KARPSCHEM LABORATORIES Varanous Labs Pvt Ltd Aurobindo Pharma Limited Lupin Ltd