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ChemicalBook > Product Catalogue >API >Digestive system drugs >Emetics and antiemetics >Azasetron hydrochloride

Azasetron hydrochloride

Azasetron hydrochloride Structure
  • ₹8941.45 - ₹36123.03
  • Product name: Azasetron hydrochloride
  • CAS: 123040-16-4
  • MF: C17H21Cl2N3O3
  • MW: 386.27
  • EINECS:692-159-3
  • MDL Number:MFCD00209913
  • Synonyms:N-(1-Azabicyclo[2.2.2]octane-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide·hydrochloride;6-chloro-3-keto-4-methyl-N-quinuclidin-3-yl-1,4-benzoxazine-8-carboxamide hydrochloride;N-{1-azabicyclo[2.2.2]octan-3-yl}-6-chloro-4-Methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxaMide;Azastron hydrochloride injection;N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-Methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxaMide hydrochloride (1:1);N-1-AZABICYCLO[2.2.2]-OCT-3-YL-6-CHLORO-3,4-DIHYDRO-4-METHYL-3-OXO-2H-1,4-BENZOXAZINE-8-CARBOXAMIDE, HYDROCHLORIDE;N-(1-AZABICYCLO[2.2.2]OCT-3-YL)-6-CHLORO-4-METHYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-8-CARBOXAMIDE HCL;N-(1-AZABICYCLO[2.2.2]OCT-3-YL)-6-CHLORO-4-METHYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-8-CARBOXAMIDE HYDROCHLORIDE
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML2491
  • Product descriptionAzasetron hydrochloride ≥98% (HPLC)
  • Packaging5MG
  • Price₹8941.45
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML2491
  • Product descriptionAzasetron hydrochloride ≥98% (HPLC)
  • Packaging25MG
  • Price₹36123.03
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML2491 Azasetron hydrochloride ≥98% (HPLC) 5MG ₹8941.45 2022-06-14 Buy
Sigma-Aldrich(India) SML2491 Azasetron hydrochloride ≥98% (HPLC) 25MG ₹36123.03 2022-06-14 Buy

Properties

Melting point :281° (dec); mp 305° (dec) (Kawakita)
storage temp. :Sealed in dry,Room Temperature
solubility :Methanol (Slightly), Water (Slightly)
form :White solid.
color :White
CAS DataBase Reference :123040-16-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Nazasetron (azasetron) hydrochloride is the fourth in the class of highly potent 5- HT3 receptor antagonists to reach the market for prophylaxis of severe nausea and vomiting induced by cytotoxic chemotherapy and by total body X-radiation. In a study with 146 cancer patients suffering from emesis induced by cisplatin, nazasetron was reported to be markedly effective in 72% of subjects. Nazasetron is devoid of dopamine D2 receptor blocking activity and therefore is free of the extrapyrimidal side effects associated with other commonly used antiemetics such as metoclopramide and domperidone. Nazasetron has been reported to be potentially useful for the treatment of gastrointestinal motility dysfunction, such as gastric stasis, vomiting and irritable bowel syndrome.

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