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BI 6015

BI 6015 Structure
  • ₹16090
  • Product name: BI 6015
  • CAS: 93987-29-2
  • MF: C15H13N3O4S
  • MW: 331.35
  • EINECS:
  • MDL Number:MFCD04406654
  • Synonyms:BI 6015;2-Methyl-1-(2-methyl-5-nitrophenylsulfonyl)-1H-benzo[d]imidazole;2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole;inhibit,promoter,HNF4α,factor,hepatocyte,Inhibitor,diabetes,insulin,BI-6015,BI6015,nuclear,cancer,BI 6015;1H-Benzimidazole, 2-methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-;B16015
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Brand

  • Sigma-Aldrich(India)

Package

  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product number375240
  • Product descriptionHNF4 Antagonist, BI6015 - CAS 93987-29-2 - Calbiochem The HNF4 Antagonist, BI6, also referenced under CAS 93987-29-2, controls the biological activity of HNF4.
  • Packaging25MG
  • Price₹16090
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 375240 HNF4 Antagonist, BI6015 - CAS 93987-29-2 - Calbiochem The HNF4 Antagonist, BI6, also referenced under CAS 93987-29-2, controls the biological activity of HNF4. 25MG ₹16090 2022-06-14 Buy

Properties

Boiling point :570.6±60.0 °C(Predicted)
Density :1.45±0.1 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml).
form :Beige powder
pka :0.88±0.10(Predicted)
color :Tan
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
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Description

Hepatocyte nuclear factor 4α (HNF4α) is a nuclear receptor transcription factor that controls the expression of many genes including those involved in glucose and lipid homeostasis and maintenance of epithelial differentiation. BI6015 is a small molecule antagonist of Hepatocyte nuclear factor 4α (HNF4α) that has been shown to repress the expression of known HNF4α target genes. At concentrations up to 20 μM, BI6015 has been shown to reduce endogenous insulin gene expression by as much as 50-fold in T6PNE cells. The hepatocytes from livers of mice injected with 10 and 30 mg/kg BI6015 exhibit marked, dose-dependent fat accumulation (steatosis). Additionally, at a daily dose of 30 mg/kg, BI6015 induces apoptosis in a human hepatocellular carcinoma mouse model.

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