BI-9564
- ₹0
- Product name: BI-9564
- CAS: 1883429-22-8
- MF: C20H23N3O3
- MW: 353.41
- EINECS:
- MDL Number:MFCD30182324
- Synonyms:BI-9564;4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one;BI-9564 (BI 9564;CS-2421;2,7-Naphthyridin-1(2H)-one, 4-[4-[(dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-;BI-9564 >=97% (HPLC);BI-9564,Inhibitor,Epigenetic Reader Domain,inhibit;4-(4-((Dimethylamino)methyl)-2,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one
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Properties
storage temp. :Store at -20°C
solubility :≥8.82 mg/mL in DMSO with ultrasonic,≥8.32 mg/mL in EtOH with ultrasonic,insoluble in H2O
form :crystalline solid
color :White to off-white
solubility :≥8.82 mg/mL in DMSO with ultrasonic,≥8.32 mg/mL in EtOH with ultrasonic,insoluble in H2O
form :crystalline solid
color :White to off-white
Safety Information
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Description
BI-9564 is a selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM; IC50s = 75 nM and 3.4 μM, respectively) that demonstrates cellular activity by semi-quantitative FRAP assay with ~90% inhibition of BRD9 and BRD7 at 0.1 μM and 1 μM, respectively. It does not bind to other bromodomain-containing BET family members (IC50s >100 μM as assessed by AlphaScreen), kinases, or G protein-coupled receptors and shows off-target selectivity only to the CECR2 bromodomain in in vitro ITC assays (Kd = 258 nM), but not in cell-based assays at concentrations up to 1 μM. BI-9564 has been shown to inhibit the growth of EOL-1 AML cells both in vitro (EC50 = 800 nM) and in a disseminated mouse model of AML (180 mg/kg/day). See the Structural Genomics Consortium (SGC) website for more information.Related product price
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Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
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TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Jilin Chinese Academy of Sciences-yanshen Technology
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Wuhan Jingkang en Biomedical Technology Co., Ltd
Amadis Chemical Company Limited