BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-
- ₹0
- Product name: BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-
- CAS: 1054543-47-3
- MF: C33H25F6N3O3
- MW: 625.56
- EINECS:604-604-1
- MDL Number:MFCD19443178
- Synonyms:BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-;Apoptosis Activator VII, Apoptozole;6-BROMO-4-CHLOROQUINOLINE HYDROCHLORIDE (1:1);5-bis(trifluoroMethyl)phenyl]-4;5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-;Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem;4-({2-[3,5-Bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)-1 H-imidazol-1-yl}methyl)benzamide;Apoptozole,Apoptosis Activator VII
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Properties
Melting point :225-228°C
Boiling point :703.5±70.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form :White solid
pka :15.98±0.50(Predicted)
color :White
Boiling point :703.5±70.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form :White solid
pka :15.98±0.50(Predicted)
color :White
Safety Information
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Description
Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity. It does not act on Hsp40, Hsp60, or Hsp90. Apoptozole dose-dependently induces apoptosis in cancer cells (IC50 = 5-7 μM). It prevents the association of Hsp70 with apoptotic protease-activating factor 1 and triggers caspase activation in HeLa cells. Apoptozole (10 mg/kg, i.p.) prevents the growth of A549, RKO, and HeLa cell xenografts in mice without significant loss of body weight.Related product price
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Suppliers and manufacturers
A.J Chemicals
ATK CHEMICAL COMPANY LIMITED
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Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
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LEAPCHEM CO., LTD.