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ChemicalBook > Product Catalogue >API >Synthetic Anti-infective Drugs >Natural source of Anti-infectives >Berberine hydrochloride

Berberine hydrochloride

Berberine hydrochloride Structure
  • ₹1305 - ₹19506.65
  • Product name: Berberine hydrochloride
  • CAS: 633-65-8
  • MF: C20H18NO4.Cl
  • MW: 371.81
  • EINECS:211-195-9
  • MDL Number:MFCD00011939
  • Synonyms:TIMTEC-BB SBB006488;NATURAL YELLOW 18 CHLORIDE;NATURAL YELLOW 18;UMBELLATINE;BERBERINE HYDROCHLORIDE;BERBERINE HYDROCHLORIDE N-HYDRATE;LABOTEST-BB LT00440956;CI 75160
7 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)
  • ottokemi

Package

  • 25MG
  • 500MG
  • 1gm
  • 5gm
  • 5G
  • 10G
  • 25G
  • ManufacturerSigma-Aldrich(India)
  • Product number200275
  • Product descriptionBerberine Chloride A highly potent and selective oxysterol EBI2 (GPR183) agonist (Kd) = 450 pM in a saturation binding assay, and EC?? = 140 pM over EC?? = 2.1 nM for it
  • Packaging25MG
  • Price₹3500
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberB3251
  • Product descriptionBerberine chloride form
  • Packaging5G
  • Price₹4459.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberB3251
  • Product descriptionBerberine chloride form
  • Packaging10G
  • Price₹7815.65
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1502
  • Product descriptionBerberine Chloride Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging500MG
  • Price₹14884.38
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberB3251
  • Product descriptionBerberine chloride form
  • Packaging25G
  • Price₹19506.65
  • Updated2022-06-14
  • Buy
  • Manufacturerottokemi
  • Product number B 1698
  • Product descriptionBerberine chloride 97%
  • Packaging1gm
  • Price₹1305
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number B 1698
  • Product descriptionBerberine chloride 97%
  • Packaging5gm
  • Price₹3807
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 200275 Berberine Chloride A highly potent and selective oxysterol EBI2 (GPR183) agonist (Kd) = 450 pM in a saturation binding assay, and EC?? = 140 pM over EC?? = 2.1 nM for it 25MG ₹3500 2022-06-14 Buy
Sigma-Aldrich(India) B3251 Berberine chloride form 5G ₹4459.9 2022-06-14 Buy
Sigma-Aldrich(India) B3251 Berberine chloride form 10G ₹7815.65 2022-06-14 Buy
Sigma-Aldrich(India) PHR1502 Berberine Chloride Pharmaceutical Secondary Standard; Certified Reference Material 500MG ₹14884.38 2022-06-14 Buy
Sigma-Aldrich(India) B3251 Berberine chloride form 25G ₹19506.65 2022-06-14 Buy
ottokemi B 1698 Berberine chloride 97% 1gm ₹1305 2022-05-26 Buy
ottokemi B 1698 Berberine chloride 97% 5gm ₹3807 2022-05-26 Buy

Properties

Melting point :204-206 °C (dec.)
storage temp. :Inert atmosphere,2-8°C
solubility :methanol: soluble
form :Yellow powder
Colour Index :75160
color :Yellow powder
Water Solubility :SOLUBLE IN COLD WATER
BRN :3836585
Stability :Hygroscopic
InChI :InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
InChIKey :VKJGBAJNNALVAV-UHFFFAOYSA-M
SMILES :C12C=C3C(C(OC)=C(OC)C=C3)=C[N+]=1CCC1=CC3=C(OCO3)C=C21.[Cl-]
CAS DataBase Reference :633-65-8
EPA Substance Registry System :Berberine chloride (633-65-8)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2 (cyclooxygenase-2) which is abundantly expressed in colon cancer cells. Also inhibits c-Jun (Activator Protein 1), a transcription factor that plays a critical role in inflammation and carcinogenesis. Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.

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