CP 91149
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- ₹14667.88 - ₹58314.28
- Product name: CP 91149
- CAS: 186392-40-5
- MF: C21H21ClN3O3
- MW: 398.86274
- EINECS:
- MDL Number:MFCD00954145
- Synonyms:[R-(R*,S*)]-5-Chloro-N-[3-(diMethylaMino)-2-hydroxy-3-oxo- 1-(phenylMethyl)propyl]-1H-indole-2-carboxaMide;5-Chloro-N-[(1S,2R)-3-(diMethylaMino)-2-hydroxy-3-oxo-1-(phenylMethyl)propyl]-1H-indole-2-carboxaMide;CP 91149;5-chloro-N-((2S,3R)-4-(dimethylamino)-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-1H-indole-2-carboxamide;CP 91149 USP/EP/BP;CS-231;CP-91149 CP91149
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberPZ0104
- Product descriptionCP-91149 ≥98% (HPLC)
- Packaging5MG
- Price₹14667.88
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberPZ0104
- Product descriptionCP-91149 ≥98% (HPLC)
- Packaging25MG
- Price₹58314.28
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | PZ0104 | CP-91149 ≥98% (HPLC) | 5MG | ₹14667.88 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | PZ0104 | CP-91149 ≥98% (HPLC) | 25MG | ₹58314.28 | 2022-06-14 | Buy |
Properties
Melting point :190-192°C
storage temp. :2-8°C
solubility :DMSO: >20mg/mL
form :powder
color :white to off-white
Stability :Hygroscopic
storage temp. :2-8°C
solubility :DMSO: >20mg/mL
form :powder
color :white to off-white
Stability :Hygroscopic
Safety Information
Symbol(GHS): |
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Signal word: | Warning | ||||||||||||||
Hazard statements: |
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Precautionary statements: |
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Description
CP 91,149 is an inhibitor of human liver glycogen phosphorylase a (LGPa), muscle glycogen phosphorylase a (MGPa), and MGPb (IC50s = 0.13, 0.2, and 0.3 μM, respectively, in the presence of glucose). CP 91,149 is 5- to 10-fold less potent in the absence of glucose. In vitro, it inhibits glucagon-stimulated glycogenolysis in primary human hepatocytes (IC50 = 2.1 μM) and increases glycogen synthesis in rat hepatocytes at a concentration of 2.5 μM in the presence of 5 mM glucose. CP 91,149 inhibits brain GP (IC50 = 0.5 μM) and, at a concentration of 30 μM, inhibits glycogen accumulation and proliferation of A549 non-small cell lung carcinoma (NSCLC) cells that express endogenous brain GP. In vivo, CP 91,149 (25 mg/kg, p.o.) lowers the plasma glucose level in diabetic ob/ob mice within 3 hours of administration without producing hypoglycemia, but has no effect on normoglycemic, non-diabetic mice.More related product prices
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