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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Epigenetics >HDAC inhibitors >CRA-02478

CRA-02478

CRA-02478 Structure
  • ₹0
  • Product name: CRA-02478
  • CAS: 783355-60-2
  • MF: C21H23N3O5
  • MW: 397.42
  • EINECS:811-183-9
  • MDL Number:MFCD10565969
  • Synonyms:CRA 024781;CRA 24781;CRA-02478;PCI-24781;PCI-24781(CRA-024781);PCI-24781;CRA-02478;3-[(Dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide;3-((diMethylaMino)Methyl)-N-(2-(4-(hydroxycarbaMoyl)phenoxy)ethyl)benzofuran-2-carboxaMide
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :198-202oC (dec.)
Density :1.284
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
form :Solid
pka :9.04±0.10(Predicted)
color :White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PCI-24781 is a novel hydroxamic acid HDAC inhibitor (histone deacetylase inhibitor). ?PCI-24781 exerts cytotoxicity and histone H3 alterations via caspase-8 and FADD in leukemia cells.