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ChemicalBook > Product Catalogue >API >Urinary System Drugs >Diuretics Drugs >CYCLOTHIAZIDE

CYCLOTHIAZIDE

CYCLOTHIAZIDE Structure
  • ₹5000 - ₹27127.45
  • Product name: CYCLOTHIAZIDE
  • CAS: 2259-96-3
  • MF: C14H16ClN3O4S2
  • MW: 389.88
  • EINECS:218-859-7
  • MDL Number:MFCD00210192
  • Synonyms:7-sulfonamide1,1-dioxide ;Anhydron;Aquirel;Doburil;Fluidil;Lilly 35483;lilly35,483 ;MDi 193
4 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 25MG
  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberC3392
  • Product descriptionCyclothiazide (mixture of isomers)
  • Packaging25MG
  • Price₹5000
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberC3392
  • Product descriptionCyclothiazide (mixture of isomers)
  • Packaging100MG
  • Price₹12500
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC9847
  • Product descriptionCyclothiazide
  • Packaging10MG
  • Price₹13195.68
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC9847
  • Product descriptionCyclothiazide
  • Packaging25MG
  • Price₹27127.45
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) C3392 Cyclothiazide (mixture of isomers) 25MG ₹5000 2022-05-26 Buy
TCI Chemicals (India) C3392 Cyclothiazide (mixture of isomers) 100MG ₹12500 2022-05-26 Buy
Sigma-Aldrich(India) C9847 Cyclothiazide 10MG ₹13195.68 2022-06-14 Buy
Sigma-Aldrich(India) C9847 Cyclothiazide 25MG ₹27127.45 2022-06-14 Buy

Properties

Melting point :234°
Density :1.3781 (rough estimate)
refractive index :1.6100 (estimate)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 9 mg/ml)
pka :pKa 9.1(30% EtOH) (Uncertain)
form :White to off-white solid.
color :Off-white
λmax :273nm(lit.)
Merck :14,2754
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
EPA Substance Registry System :2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-, 1,1-dioxide (2259-96-3)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

Receptors for AMPA are ionotropic glutamate receptors with critical roles in neurological development and function. Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptors, positively modulating its response to glutamic acid (EC50 = 3.8 μM). It blocks the rapid agonist-induced desensitization of AMPA receptors, resulting in enhanced excitatory activity. Cyclothiazide is also a negative modulator of GABAA receptors, reversibly inhibiting both evoked and spontaneous inhibitory postsynaptic currents (IC50 = 58 μM).

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