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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Alkylating antineoplastic >Carmustine

Carmustine

Carmustine Structure
  • ₹8356.9 - ₹32345.1
  • Product name: Carmustine
  • CAS: 154-93-8
  • MF: C5H9Cl2N3O2
  • MW: 214.05
  • EINECS:205-838-2
  • MDL Number:MFCD00057706
  • Synonyms:Carmustine, >=98%;1,3-BIS(2-CHLOROETHYL)NITROSOUREA;1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA;DTI 015;CarMustine/BCNU;Carmustine (75 mg) (COLD SHIPMENT REQUIRED);Carmustinum;Gliadel
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)
  • TCI Chemicals (India)

Package

  • 25MG
  • 100MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberC0400
  • Product descriptionCarmustine ≥98%
  • Packaging25MG
  • Price₹8356.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC0400
  • Product descriptionCarmustine ≥98%
  • Packaging100MG
  • Price₹32345.1
  • Updated2022-06-14
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberC2634
  • Product descriptionCarmustine
  • Packaging100MG
  • Price₹13200
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) C0400 Carmustine ≥98% 25MG ₹8356.9 2022-06-14 Buy
Sigma-Aldrich(India) C0400 Carmustine ≥98% 100MG ₹32345.1 2022-06-14 Buy
TCI Chemicals (India) C2634 Carmustine 100MG ₹13200 2022-05-26 Buy

Properties

Melting point :30 °C (lit.)
Density :1.6948 (rough estimate)
refractive index :1.6100 (estimate)
storage temp. :-20°C
solubility :insoluble in H2O; ≥21.51 mg/mL in DMSO; ≥27.15 mg/mL in EtOH
form :(Oily liquid to amorphous solid)
pka :10.19±0.46(Predicted)
color :Light-yellow powder
Water Solubility :<0.1 g/100 mL at 18 ºC
Merck :14,1845
Stability :Temperature Sensitive
InChIKey :DLGOEMSEDOSKAD-UHFFFAOYSA-N
CAS DataBase Reference :154-93-8(CAS DataBase Reference)
IARC :2A (Vol. 26, Sup 7) 1987
EPA Substance Registry System :1,3-Bis(2-chloroethyl)-1-nitrosourea (154-93-8)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Carmustine is a nitrogen mustard β-chloro-nitrosourea compound that is used as an alkylating agent. It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading to apoptosis. Carmustine is also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase. Carmustine has been tested in clinical trials as a cytostatic agent for Hodgkin’s and non-Hodgkin’s lymphoma, myeloma, malignant melanoma, glioblastoma, and other brain tumors.

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