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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >GPCR & G Protein >CaSR activator >Cinacalcet hydrochloride

Cinacalcet hydrochloride

Cinacalcet hydrochloride Structure
  • ₹7978.03 - ₹32280.15
  • Product name: Cinacalcet hydrochloride
  • CAS: 364782-34-3
  • MF: C22H23ClF3N
  • MW: 393.88
  • EINECS:620-490-5
  • MDL Number:MFCD08067750
  • Synonyms:(aR)-a-Methyl-N-[3-[3-(trifluoromethyl)phenyl)propyl]-1-napthalenemethanamine Hydrochloride;(R)-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1- -(1-napthyl)ethylamine Hydrochloride;Cinacalcet Hydrochloride;N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride;-Naphthalenemethanamine, .alpha.-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, hydrochloride (1:1), (.alpha.R)-;(aR)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl)propyl]-1-napthalenemethanamine Hydrochloride;N-[(1R)-1-naphthalen-1-yleth;[(1R)-1-(naphthalen-1-yl)ethyl]({3-[3-(trifluoroMethyl)phenyl]propyl})aMine hydrochloride
2 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML2012
  • Product descriptionCinacalcet hydrochloride ≥98% (HPLC)
  • Packaging10MG
  • Price₹7978.03
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML2012
  • Product descriptionCinacalcet hydrochloride ≥98% (HPLC)
  • Packaging50MG
  • Price₹32280.15
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML2012 Cinacalcet hydrochloride ≥98% (HPLC) 10MG ₹7978.03 2022-06-14 Buy
Sigma-Aldrich(India) SML2012 Cinacalcet hydrochloride ≥98% (HPLC) 50MG ₹32280.15 2022-06-14 Buy

Properties

Melting point :175-177°C
storage temp. :Inert atmosphere,2-8°C
solubility :insoluble in H2O; ≥17.85 mg/mL in DMSO; ≥56 mg/mL in EtOH
form :solid
color :White to off-white
InChI :InChI=1/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/s3
InChIKey :QANQWUQOEJZMLL-LSQUZMQTNA-N
SMILES :C12C=CC=CC1=CC=CC=2[C@@H](C)NCCCC1=CC=CC(C(F)(F)F)=C1.Cl |&1:10,r|
CAS DataBase Reference :364782-34-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger GHS hazard pictograms P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P314 Get medical advice/attention if you feel unwell.

Description

Cinacalcet is a calcimimetic that allosterically activates the calcium-sensing receptor (CaSR; pEC50 = 7.3 in HEK293T cells expressing CaSR). In the presence of calcium ions, it can inhibit parathyroid hormone secretion by activating CaSR in parathyroid glands. Cinacalcet has been used clinically to treat secondary hyperparathyroidism due to end-stage renal disease or hypercalcemia in patients with parathyroid carcinoma.

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