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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Antimetabolites, Antineoplastic >Clofarabine

Clofarabine

Clofarabine Structure
  • ₹2600 - ₹45865.53
  • Product name: Clofarabine
  • CAS: 123318-82-1
  • MF: C10H11ClFN5O3
  • MW: 303.68
  • EINECS:631-422-9
  • MDL Number:MFCD00871077
  • Synonyms:2-CHLORO-2'-ARABINOFLUORO-2'-DEOXYADENOSINE;5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol;CLOFARABINE;CAFDA;2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin ;2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)adenine ;Clofarabine2-CHLORO-9-(2'-DEOXY-2'-FLUORO-B-D-ARABINOFURANOSYL)ADENINE;5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
Price4 Properties Safety Information Description
4 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 20MG
  • 25MG
  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberC2500
  • Product descriptionClofarabine
  • Packaging20MG
  • Price₹2600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberC2500
  • Product descriptionClofarabine
  • Packaging100MG
  • Price₹6400
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC7495
  • Product descriptionClofarabine ≥98% (HPLC)
  • Packaging5MG
  • Price₹11387.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC7495
  • Product descriptionClofarabine ≥98% (HPLC)
  • Packaging25MG
  • Price₹45865.53
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) C2500 Clofarabine 20MG ₹2600 2022-05-26 Buy
TCI Chemicals (India) C2500 Clofarabine 100MG ₹6400 2022-05-26 Buy
Sigma-Aldrich(India) C7495 Clofarabine ≥98% (HPLC) 5MG ₹11387.9 2022-06-14 Buy
Sigma-Aldrich(India) C7495 Clofarabine ≥98% (HPLC) 25MG ₹45865.53 2022-06-14 Buy

Properties

Melting point :228-2310C
Boiling point :550.0±60.0 °C(Predicted)
Density :1.4804 (estimate)
RTECS :UD7473000
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :Powder
pka :12.56±0.70(Predicted)
color :white
λmax :263nm(EtOH)(lit.)
Merck :14,2372
InChIKey :INHHKRVRRUIAPA-KJHIFWANSA-N
CAS DataBase Reference :123318-82-1(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Clofarabine is a nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-α (IC50s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC50 = 5 nM). It induces apoptosis in primary chronic lymphocytic leukemia cells by directly altering mitochondrial transmembrane potential. Clofarabine demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.

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Alembic Pharmaceuticals Limited Shilpa Medicare Limited (SML) Ralington Pharma Sakar Healthcare Biophore India Pharmaceuticals Pvt Ltd BDR Pharmaceuticals International Pvt Ltd Mylan Laboratories Ltd Apicore Pharmaceuticals Pvt Ltd Aspen Biopharma Labs Pvt Ltd EMCURE PHARMACEUTICALS LTD