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ChemicalBook > Product Catalogue >Pharmaceutical intermediates >Bulk Drug Intermediates >Dapagliflozin

Dapagliflozin

Dapagliflozin Structure
  • ₹0
  • Product name: Dapagliflozin
  • CAS: 461432-26-8
  • MF: C21H25ClO6
  • MW: 408.88
  • EINECS:639-683-0
  • MDL Number:MFCD13182359
  • Synonyms:Dapagliflozin(BMS-512148);1-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-1-deoxy-beta-D-glucopyranose (1S)-1,5-Anhydro-1-C-[4-chloro-3-(4-ethoxybenzyl)phenyl]-D-glucitol (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxyMethyl)tetrahydro-2H-pyran-3,4,5-triol;(2S,3R,4R,5S,6R)-2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxyMethyltetrahydro-2H-pyran-3,4,5-triol;1-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-1-deoxy-beta-D-glucopyranose;BMS5121458;Dag coluMn net;Dapagliflozin Isomer Impurity;Dapagliflozin, >=98%
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :55-58°C
Boiling point :609.0±55.0 °C(Predicted)
Density :1.349
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :13.23±0.70(Predicted)
form :Solid
color :White to Pale Yellow
Stability :Hygroscopic

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P314 Get medical advice/attention if you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

Inhibiting renal glucose reabsorbtion through the sodium-glucose cotransporter (SGLT) offers an insulin-independent alternative to controlling blood glucose concentrations in patients with type 2 diabetes. While the majority of glucose is reabsorbed from glomerular filtrate by SGLT2, which is predominantly expressed in the kidney S1 segment of the proximal tubule, SGLT1 reabsorbs glucose in the distal S3 segment of the renal proximal tubule as well as from the small intestine. Dapagliflozin is a first generation, selective SGLT inhibitor that blocks glucose transport with about 100-fold selectivity for SGLT2 (Ki = 6 nM; EC50 = 1.1 nM) over SGLT1 (Ki = 390 nM). After single oral doses ranging from 0.1 to 1.0 mg/kg, dapagliflozin increases urinary glucose excretion in both normal and diabetic rats, improves glucose tolerance in normal rats, and reduces hyperglycemia in Zucker diabetic fatty rats. Within two weeks of treating diabetic rats with 0.1 to 1.0 mg/kg dapagliflozin, fasting and fed glucose levels have been shown to be significantly lowered as a result of increased glucose utilization accompanied by reduced glucose production.

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Suppliers and manufacturers

TAGOOR LABORATORIES PVT LTD HEMA PHARMACEUTICALS PVT LTD SGMR PHARMACEUTICALS PVT LTD Dr. Reddy's Laboratories Ltd SKVen Technologies Pvt.Ltd. Flax Laboratories AARTIA KEM SCIENCE TYNDAL LABS PVT LTD Varanous Labs Pvt Ltd Metrochem API Private Limited