E-4031

₹18597.35 - ₹123448.3
Product name: E-4031
CAS: 113559-13-0
MF: C21H33Cl2N3O5S
MW: 510.47
EINECS:
MDL Number:MFCD00889193
Synonyms:1-(2-(6-methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidined ;methanesulfonamide,n-(4-((1-(2-(6-methyl-2-pyridinyl)ethyl)-4-piperidinyl)carb ;E-4031;N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride;N-[4-[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinylcarbonyl]phenyl]methanesulfonamide·2hydrochloric acid;E-4031 (hydrochloride);N-(4-(1-(2-(6-METHYLPYRIDIN-2-YL)ETHYL)PIPERIDINE-4-CARBONYL)PHENYL)METHANESULFONAMIDE 2HCL;N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide dihydrochloride

Price3 Properties Safety Information Description

3 prices

Selected condition：

Brand

Sigma-Aldrich(India)

Package

0.1MG
0.5MG
1MG

ManufacturerSigma-Aldrich(India)
Product numberM5060
Product descriptionE-4031 ≥98% (HPLC), lyophilized powder
Packaging0.1MG
Price₹18597.35
Updated2022-06-14
Buy

ManufacturerSigma-Aldrich(India)
Product numberM5060
Product descriptionE-4031 ≥98% (HPLC), lyophilized powder
Packaging0.5MG
Price₹65263.93
Updated2022-06-14
Buy

ManufacturerSigma-Aldrich(India)
Product numberM5060
Product descriptionE-4031 ≥98% (HPLC), lyophilized powder
Packaging1MG
Price₹123448.3
Updated2022-06-14
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	M5060	E-4031 ≥98% (HPLC), lyophilized powder	0.1MG	₹18597.35	2022-06-14	Buy
Sigma-Aldrich(India)	M5060	E-4031 ≥98% (HPLC), lyophilized powder	0.5MG	₹65263.93	2022-06-14	Buy
Sigma-Aldrich(India)	M5060	E-4031 ≥98% (HPLC), lyophilized powder	1MG	₹123448.3	2022-06-14	Buy

Properties

storage temp. :-20°C
solubility :H2O: soluble
form :solid
color :off-white
Stability :Hygroscopic

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning		P264, P270, P301+P312, P330, P501

Precautionary statements:

P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P301+P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330	Rinse mouth.
P501	Dispose of contents/container to..…

Description

Voltage-gated potassium ERG channels (Kv11.1), encoded by the ether-a-go-go related gene, mediate the inwardly rectifying potassium (K+) current that repolarizes myocardial cells, gut smooth muscle cells, and interstitial cells of Cajal. E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM). E-4031 inhibits the ERG1, ERG2, and ERG3 isoforms with KD values of 99, 116, and 193 nM, respectively. However, at higher μM concentrations E-4031 can demonstrate pro-arrhythmic activity, inducing early after depolarizations (prolonged repolarization) in cell models and torsade de pointes in animal models. E-4031 has been used to pharmacologically rescue misprocessed ERG in long QT syndrome type 2, an autosomal dominant cardiac disease associated with prolongation of the QT interval and torsade de pointes.

More related product prices

N-Methylbenzylamine Betahistine dihydrochloride