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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Proteases >Cysteine ??Protease Inhibitors >EST

EST

EST Structure
  • ₹6600 - ₹48240.6
  • Product name: EST
  • CAS: 88321-09-9
  • MF: C17H30N2O5
  • MW: 342.43
  • EINECS:
  • MDL Number:MFCD00132883
  • Synonyms:COT (30-397), active, GST tagged human;2-Oxiranecarboxylicacid,3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-,ethyl ester, (2S,3S)-;E 64d (Aloxistatin);(2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]-butyl]amino]carbonyl]-2-oxiranec;L-TRANS-EPOXYSUCCINYL-LEU-3-METHYLBUTYLAMIDE-ETHYL ESTER;L-TRANS-EPOXYSUCCINYL(OET)-LEU-3-METHYLBUTYLAMIDE;LOXASTATIN;LOXISTATIN
Price6 Properties Safety Information Description
6 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 1MG
  • 10μG
  • 250μG
  • 5MG
  • 25MG
  • ManufacturerTCI Chemicals (India)
  • Product numberE1337
  • Product descriptionE-64d [for Biochemical Research]
  • Packaging5MG
  • Price₹6600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberE1337
  • Product descriptionE-64d [for Biochemical Research]
  • Packaging25MG
  • Price₹15000
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberE8640
  • Product descriptionE-64d protease inhibitor
  • Packaging250μG
  • Price₹15782.85
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number330005
  • Product descriptionEST - CAS 88321-09-9 - Calbiochem A cell-permeable, irreversible inhibitor of cysteine proteases.
  • Packaging1MG
  • Price₹16670.01
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberE8640
  • Product descriptionE-64d protease inhibitor
  • Packaging1MG
  • Price₹43343.3
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC1370
  • Product descriptionCOT (30-397), active, GST tagged human PRECISIO? Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
  • Packaging10μG
  • Price₹48240.6
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) E1337 E-64d [for Biochemical Research] 5MG ₹6600 2022-05-26 Buy
TCI Chemicals (India) E1337 E-64d [for Biochemical Research] 25MG ₹15000 2022-05-26 Buy
Sigma-Aldrich(India) E8640 E-64d protease inhibitor 250μG ₹15782.85 2022-06-14 Buy
Sigma-Aldrich(India) 330005 EST - CAS 88321-09-9 - Calbiochem A cell-permeable, irreversible inhibitor of cysteine proteases. 1MG ₹16670.01 2022-06-14 Buy
Sigma-Aldrich(India) E8640 E-64d protease inhibitor 1MG ₹43343.3 2022-06-14 Buy
Sigma-Aldrich(India) C1370 COT (30-397), active, GST tagged human PRECISIO? Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution 10μG ₹48240.6 2022-06-14 Buy

Properties

Melting point :126.2°C
Boiling point :477.88°C (rough estimate)
Density :1.0657 (rough estimate)
refractive index :1.5800 (estimate)
storage temp. :-20°C
solubility :Soluble in DMSO, DMF or ethanol
pka :13.32±0.40(Predicted)
form :White solid
color :Fine needles from EtOH
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

Cysteine proteases are a class of enzymes containing an active-site cysteine residue that is important in protein degradation pathways E-64d, a synthetic analog of E-64 and ethyl ester of E-64c, is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases. E-64d inhibits calpain and the cysteine proteases cathepsins F, K, B, H, and L. By disrupting protease activity, E-64d, at concentrations between 20-200 μM, has been shown to arrest human epidermoid carcinoma A431 cells at mitotic metaphase. It also inhibits protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells with an IC50 value of 0.5 μM.

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Suppliers and manufacturers

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