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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >DNA damage >DNA / RNA Synthesis inhibitors >FidaxoMicin

FidaxoMicin

FidaxoMicin Structure
  • ₹6600 - ₹34932.28
  • Product name: FidaxoMicin
  • CAS: 873857-62-6
  • MF: C52H74Cl2O18
  • MW: 1058.04
  • EINECS:
  • MDL Number:MFCD27976367
  • Synonyms:FidaxoMicin;3-(((6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-b-D-mannopyranosyl)oxy)-methyl)-12(R)-[(6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-b-D-lyxo-hexopyranosyl)oxy]-11(S)-ethyl-8(S)-hydroxy-18(S)-(1(R)-hydroxyethyl)-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaene-2-one;OPT-80;PAR-101;R-Tiacumicin B;Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-, (3E,5E,8S,9E,11S,12R,13E,15E,18S)-;3-(((6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-b-D-mannopyranosyl)oxy)-methyl)-12(R)-[(6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-b-D-lyxo-hexopyranosyl)oxy]-11(S)-eth;Fidaxomicin R-Tiacumicin B
3 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 1MG
  • 25MG
  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberF1216
  • Product descriptionFidaxomicin
  • Packaging25MG
  • Price₹6600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberF1216
  • Product descriptionFidaxomicin
  • Packaging100MG
  • Price₹14800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1750
  • Product descriptionFidaxomicin ≥98% (HPLC)
  • Packaging1MG
  • Price₹34932.28
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) F1216 Fidaxomicin 25MG ₹6600 2022-05-26 Buy
TCI Chemicals (India) F1216 Fidaxomicin 100MG ₹14800 2022-05-26 Buy
Sigma-Aldrich(India) SML1750 Fidaxomicin ≥98% (HPLC) 1MG ₹34932.28 2022-06-14 Buy

Properties

Melting point :161 °C
Boiling point :1046.4±65.0 °C(Predicted)
Density :1.33
storage temp. :2-8°C
solubility :Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly)
form :powder
pka :5.09±0.35(Predicted)
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).

Description

Fidaxomycin is a natural macrocyclic antibiotic that inhibits RNA polymerase with selectivity for Gram-positive bacteria over Gram-negative bacteria (IC50s = 0.4 and 6 μM, respectively). It has potent antibacterial activity against most Gram-positive bacteria and effectively targets the Gram-positive C. difficile (MIC = 12 ng/ml). Orally administered fidaxomycin exhibits minimal systemic bioavailability resulting in maximal gastrointestinal tract distribution. Fidaxomycin is effective in clearing C. difficile infections while sparing Gram-negative bacteria in the gut.

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