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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Autophagy >LRRK2 inhibitors >GNE 7915

GNE 7915

GNE 7915 Structure
  • ₹0
  • Product name: GNE 7915
  • CAS: 1351761-44-8
  • MF: C19H21F4N5O3
  • MW: 443.4
  • EINECS:
  • MDL Number:MFCD25977005
  • Synonyms:GNE 7915;[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone;GNE-7915, >=98%;(4-((4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morphol;(4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone;CS-1279;GNE7915; GNE 7915;Methanone, [4-[[4-(ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinyl-
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :143 - 144°C
Boiling point :629.9±65.0 °C(Predicted)
Density :1.404±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Chloroform (Slightly), DMSO (Slightly)
form :solid
pka :2.80±0.10(Predicted)
color :Off-white to light yellow
CAS DataBase Reference :1351761-44-8

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.

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Suppliers and manufacturers

career henan chemical co
GNE 7915
₹1.00 /1g
GNE 7915 CAS:1351761-44-8
A.J Chemicals CLEARSYNTH LABS LTD.
ATK CHEMICAL COMPANY LIMITED
Accela ChemBio Inc.
BOC Sciences
TargetMol Chemicals Inc.
Shanghai Gubang New Materail Technology Co. LTD
Dideu Industries Group Limited
InvivoChem