GNE-9605
- ₹0
- Product name: GNE-9605
- CAS: 1536200-31-3
- MF: C17H20ClF4N7O
- MW: 449.83
- EINECS:
- MDL Number:MFCD28167997
- Synonyms:GNE-9605;N2-(5-chloro-1-(3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;rel-N2-[5-Chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-2,4-pyrimidinediamine;Diazepam-d8 (exempt preparation);CS-1831;GNE-9605;GNE9605;GNE 9605;2,4-Pyrimidinediamine, N2-[5-chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-, rel-;GNE-9605 USP/EP/BP
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
Boiling point :587.9±60.0 °C(Predicted)
Density :1.67±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :≥22.5 mg/mL in DMSO
form :solid
pka :5.04±0.60(Predicted)
color :White to off-white
Density :1.67±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :≥22.5 mg/mL in DMSO
form :solid
pka :5.04±0.60(Predicted)
color :White to off-white
Safety Information
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Description
GNE-9065 is an orally bioavailable and potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 18.7 nM). It is selective for LRRK2 over 178 kinases, inhibiting only TAK1-TAB1 >50% at a concentration of 0.1 μM. GNE-9065 (10 and 50 mg/kg) inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S mutation found in families with autosomal Parkinson’s disease.More related product prices
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