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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Autophagy >LRRK2 inhibitors >GNE-9605

GNE-9605

GNE-9605 Structure
  • ₹0
  • Product name: GNE-9605
  • CAS: 1536200-31-3
  • MF: C17H20ClF4N7O
  • MW: 449.83
  • EINECS:
  • MDL Number:MFCD28167997
  • Synonyms:GNE-9605;N2-(5-chloro-1-(3-fluoro-1-(oxetan-3-yl)piperidin-4-yl)-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine;rel-N2-[5-Chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-2,4-pyrimidinediamine;Diazepam-d8 (exempt preparation);CS-1831;GNE-9605;GNE9605;GNE 9605;2,4-Pyrimidinediamine, N2-[5-chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-, rel-;GNE-9605 USP/EP/BP
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :587.9±60.0 °C(Predicted)
Density :1.67±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :≥22.5 mg/mL in DMSO
form :solid
pka :5.04±0.60(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Description

GNE-9065 is an orally bioavailable and potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 18.7 nM). It is selective for LRRK2 over 178 kinases, inhibiting only TAK1-TAB1 >50% at a concentration of 0.1 μM. GNE-9065 (10 and 50 mg/kg) inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S mutation found in families with autosomal Parkinson’s disease.

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