HELENALIN
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- ₹0
- Product name: HELENALIN
- CAS: 6754-13-8
- MF: C15H18O4
- MW: 262.3
- EINECS:
- MDL Number:MFCD01674580
- Synonyms:(3as-(3aalpha,4alpha,4abeta,7aalpha,8alpha,9aalpha))-ethyl-3-methylene ;HELENALIN(SH);HELENALIN;6alpha,8beta-dihydroxy-4-oxoambrosa-2,11(13)-dien-12-oicacid12,8-lactone ;a-dimethyl-3-methyleneazuleno[6,5-b]-furan-2,5-dione ;ambrosa-2,11(13)-dien-12-oicacid,6-alpha,8-beta-dihydroxy-4-oxo-,12,8-lacton ;ambrosa-2,11(13)-dien-12-oicacid,6alpha,8beta-dihydroxy-4-oxo-,12,8-lactone ;azuleno(6,5-b)furan-2,5-dione,3,3a,4,4a,7a,8,9,9a-octahydro-4-hydroxy-4a,8-dim
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Properties
Melting point :167-168°
alpha :D25 -102.8° (c = 3.64 in 95% ethanol)
Boiling point :325.55°C (rough estimate)
Density :1.0772 (rough estimate)
refractive index :1.4300 (estimate)
storage temp. :-20°
solubility :Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml).
form :White to off-white solid.
pka :13.29±0.60(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
LogP :0.870
alpha :D25 -102.8° (c = 3.64 in 95% ethanol)
Boiling point :325.55°C (rough estimate)
Density :1.0772 (rough estimate)
refractive index :1.4300 (estimate)
storage temp. :-20°
solubility :Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml).
form :White to off-white solid.
pka :13.29±0.60(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
LogP :0.870
Safety Information
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Description
Helenalin is a sesquiterpene lactone first isolated from various species of Arnica. It has anti-inflammatory effects, most notably by inhibiting gene expression mediated by NF-κB at doses from 1 to 20 μM. Like other sesquiterpene lactones, helenalin can modify sulfhydryl groups of cysteine residues and it alkylates these groups on the p65 subunit of NF-κB. It also suppresses the proliferation of cancer cells through multiple mechanisms, including the prevention of signaling through NF-κB. Helenalin has antibacterial and anti-protozoal activities.Related product price
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Suppliers and manufacturers
Pharmaffiliates Analytics and Synthetics P. Ltd
CLEARSYNTH LABS LTD.
Pharma Affiliates
TargetMol Chemicals Inc.
Career Henan Chemica Co
ANHUI WITOP BIOTECH CO., LTD
Dideu Industries Group Limited
Shanghai Acmec Biochemical Technology Co., Ltd.
SHANGHAI KEAN TECHNOLOGY CO., LTD.
