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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Nuclear transcription factor (NF-κB) >IκB / IKK inhibitors >BAY 11-7085

BAY 11-7085

BAY 11-7085 Structure
  • ₹7300 - ₹24800
  • Product name: BAY 11-7085
  • CAS: 196309-76-9
  • MF: C13H15NO2S
  • MW: 249.33
  • EINECS:
  • MDL Number:MFCD01862602
  • Synonyms:BAY 117083 (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile;(2E)-3-[[4-(1,1-DIMETHYLETHYL)PHENYL]SULFONYL]-2-PROPENENITRILE;(E)-3-(T-BUTYLPHENYLSULFONYL)-2-PROPENENITRILE;(E)3-[(4-T-BUTYLPHENYL)SULFONYL]-2-PROPENENITRILE;BAY 11-7085;(E)-3-(4-tert-butylphenylsulfonyl)acrylonitrile;BAY 117083;(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile BAY 11-7085
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberB4845
  • Product descriptionBAY 11-7085
  • Packaging10MG
  • Price₹7300
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB4845
  • Product descriptionBAY 11-7085
  • Packaging100MG
  • Price₹24800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberB5681
  • Product descriptionBay 11-7085 ≥98% (HPLC), solid
  • Packaging10MG
  • Price₹16551.43
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) B4845 BAY 11-7085 10MG ₹7300 2022-05-26 Buy
TCI Chemicals (India) B4845 BAY 11-7085 100MG ₹24800 2022-05-26 Buy
Sigma-Aldrich(India) B5681 Bay 11-7085 ≥98% (HPLC), solid 10MG ₹16551.43 2022-06-14 Buy

Properties

Melting point :80-82℃
Boiling point :407.1±45.0 °C(Predicted)
Density :1.144
Flash point :200℃
storage temp. :Sealed in dry,Room Temperature
solubility :DMSO: >25 mg/mL, soluble
form :solid
color :white
Sensitive :Light Sensitive
InChIKey :VHKZGNPOHPFPER-ONNFQVAWSA-N
CAS DataBase Reference :196309-76-9

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

In the classical pathway of NF-κB activation, phosphorylation of the inhibitor of NF-κB (IκBα) releases the inhibitor from NF-κB, allowing IκBα degradation and NF-κB activation and nuclear import. BAY-11-7085 is an irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM). It blocks gene expression that is regulated through the classical pathway of NF-κB activation and in this way blocks apoptosis, cell adhesion, and inflammation. BAY-11-7085 is also used to study IκBα actions that are independent of NF-κB signaling.

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Suppliers and manufacturers

career henan chemical co
BAY 11-7085
₹1.00 /1g
BAY 11-7085 CAS:196309-76-9
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