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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Nuclear transcription factor (NF-κB) >NF-κB inhibitor >6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE

6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE

6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE Structure
  • ₹15795.3 - ₹64224.6
  • Product name: 6-AMINO-4-(4-PHENOXYPHENYLETHYLAMINO)QUINAZOLINE
  • CAS: 545380-34-5
  • MF: C22H20N4O
  • MW: 356.42
  • EINECS:
  • MDL Number:MFCD06411436
  • Synonyms:QNZ;EVP 4593;EVP4593;EVP-4593;4,6-Quinazolinediamine, N4-[2-(4-phenoxyphenyl)ethyl]-;4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine;N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediaMine;QNZ (EVP4593)
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0579
  • Product descriptionEVP4593 ≥98% (HPLC)
  • Packaging5MG
  • Price₹15795.3
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number481406
  • Product descriptionNF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem The NF-κB Activation Inhibitor, also referenced under CAS 545380-34-5, controls the biological activity of NF-κB. This small molecule/inhibitor is pri
  • Packaging1MG
  • Price₹16250.01
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0579
  • Product descriptionEVP4593 ≥98% (HPLC)
  • Packaging25MG
  • Price₹64224.6
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0579 EVP4593 ≥98% (HPLC) 5MG ₹15795.3 2022-06-14 Buy
Sigma-Aldrich(India) 481406 NF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem The NF-κB Activation Inhibitor, also referenced under CAS 545380-34-5, controls the biological activity of NF-κB. This small molecule/inhibitor is pri 1MG ₹16250.01 2022-06-14 Buy
Sigma-Aldrich(India) SML0579 EVP4593 ≥98% (HPLC) 25MG ₹64224.6 2022-06-14 Buy

Properties

Melting point :169-175°C
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :DMSO: soluble15mg/mL, clear
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Description

QNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling. Improper activation of NF-κB has been linked to cancer, immune and inflammatory diseases, and viral infection. Research results suggest that QNZ fully blocks the increase in K currents in rat sensory neurons. QNZ has been used to study colorectal cancer and Schwann cell functioning.

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