IOX2
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- ₹12611.13 - ₹48777.45
- Product name: IOX2
- CAS: 931398-72-0
- MF: C19H16N2O5
- MW: 352.34
- EINECS:804-733-4
- MDL Number:MFCD22580424
- Synonyms:Glycine, N-[[1,2-dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-;N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine IOX2;JICL38;N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-glycine;(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycine;IOX 2, >=98%;IOX2;IOX 2;IOX-2;JICL38;IOX2
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0652
- Product descriptionIOX2 ≥98% (HPLC)
- Packaging5MG
- Price₹12611.13
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0652
- Product descriptionIOX2 ≥98% (HPLC)
- Packaging25MG
- Price₹48777.45
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0652 | IOX2 ≥98% (HPLC) | 5MG | ₹12611.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0652 | IOX2 ≥98% (HPLC) | 25MG | ₹48777.45 | 2022-06-14 | Buy |
Properties
Boiling point :642.8±55.0 °C(Predicted)
Density :1.470±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :3.61±0.10(Predicted)
form :powder
color :white to beige
InChIKey :CAOSCCRYLYQBES-UHFFFAOYSA-N
Density :1.470±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :3.61±0.10(Predicted)
form :powder
color :white to beige
InChIKey :CAOSCCRYLYQBES-UHFFFAOYSA-N
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
Hypoxia-inducible factor (HIF) is regulated by the hydroxylation of prolyl residues in oxygen-dependent degradation domains in the HIF-1α subunit, which mark it for degradation by the proteasome. HIF prolyl hydroxylation is catalyzed by prolyl hydroxylase domain enzymes (PHD1, 2, and 3), members of the Fe(II) and 2-oxoglutarate (2OG) oxygenase family. They require dioxygen as a cosubstrate, thus acting as the hypoxia-sensing component of the HIF system. The activity of PHD is suppressed by hypoxia, increasing both the abundance and activity of the HIF transcriptional complex. IOX2 potently inhibits PHD2 (IC50 = 21 nM) with over 100-fold selectivity compared to inhibition of JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH (IC50s > 100 μM). IOX2 is active in cells, inhibiting HIF-1α hydroxylation in RCC4 cells at 50 μM. See the Structural Genomics Consortium (SGC) website for more information.Related product price
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