IWP L6
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- ₹23559.99
- Product name: IWP L6
- CAS: 1427782-89-5
- MF: C25H20N4O2S2
- MW: 472.58
- EINECS:-0
- MDL Number:MFCD27937771
- Synonyms:IWP L6;2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyriMidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetaMide;N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide;Porcn Inhibitor III;N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide IWP-L6;2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide;IWP-L6, >=98%;2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl
2 prices
Selected condition：
Brand
- Sigma-Aldrich
- Sigma-Aldrich(India)
Package
- 10MG
- ManufacturerSigma-Aldrich
- Product number5.04819
- Product descriptionPorcn Inhibitor III, IWP-L6 - CAS 1427782-89-6 - Calbiochem
- Packaging10MG
- Price₹23559.99
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number5.04819
- Product descriptionPorcn Inhibitor III, IWP-L6 - CAS 1427782-89-6 - Calbiochem
- Packaging10MG
- Price₹23559.99
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.04819 | Porcn Inhibitor III, IWP-L6 - CAS 1427782-89-6 - Calbiochem | 10MG | ₹23559.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 5.04819 | Porcn Inhibitor III, IWP-L6 - CAS 1427782-89-6 - Calbiochem | 10MG | ₹23559.99 | 2022-06-14 | Buy |
Properties
storage temp. :Store at -20° C
solubility :≥22.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
color :White to off-white
solubility :≥22.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
color :White to off-white
Safety Information
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Description
Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. IWP-L6 is a potent inhibitor of PORCN (EC50 = 0.5 nM). It suppresses the phosphorylation of disheveled 2 in HEK293 cells. IWP-L6 displays high stability in human plasma (t1/2 > 24 hours) and in zebrafish, but it is much less stable in plasma from mice and rats. In zebrafish, IWP-L6 blocks Wnt/β-catenin-dependent developmental processes, including tailfin regeneration and posterior axis formation. It also completely prevents branching morphogenesis in cultured mouse embryonic kidneys at doses of 50 nM and above, indicating complete inhibition of Wnt signaling.Suppliers and manufacturers
career henan chemical co
![2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetamide](https://img.chemicalbook.com/ProductImageEN/2020-1/small/e55d4c66-a332-4e15-91ed-47ed57b28964.png)
A.J Chemicals
ATK CHEMICAL COMPANY LIMITED
TargetMol Chemicals Inc.
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Jilin Chinese Academy of Sciences-yanshen Technology
Aladdin Scientific
Amadis Chemical Company Limited
₹1.00 /1KG
2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetamide CAS:1427782-89-5
2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetamide CAS:1427782-89-5