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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Stem Cells & Wnt >Wnt / beta-catenin inhibitors >FH 535

FH 535

FH 535 Structure
  • ₹10814.18 - ₹41762.85
  • Product name: FH 535
  • CAS: 108409-83-2
  • MF: C13H10Cl2N2O4S
  • MW: 361.2
  • EINECS:
  • MDL Number:MFCD01212888
  • Synonyms:β-Catenin/Tcf Inhibitor, FH535;FH 535(FH-535);FH535;FH 535;FH-535;FH 535;N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonaMide;2,5-Dichloro-N-(2-Methyl-4-nitrophenyl)benzenesulfonaMide;2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide FH535;β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 10MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product number219330
  • Product descriptionβ-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem The β-Catenin/Tcf Inhibitor, FH535, also referenced under CAS 108409-83-2, controls the biological activity of β-Catenin/Tcf. This small molecule/inhi
  • Packaging10MG
  • Price₹12740
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberF5682
  • Product descriptionFH535 ≥98% (HPLC)
  • Packaging25MG
  • Price₹41762.85
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberF5682
  • Product descriptionFH535 ≥98% (HPLC)
  • Packaging5MG
  • Price₹10814.18
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 219330 β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem The β-Catenin/Tcf Inhibitor, FH535, also referenced under CAS 108409-83-2, controls the biological activity of β-Catenin/Tcf. This small molecule/inhi 10MG ₹12740 2022-06-14 Buy
Sigma-Aldrich(India) F5682 FH535 ≥98% (HPLC) 25MG ₹41762.85 2022-06-14 Buy
Sigma-Aldrich(India) F5682 FH535 ≥98% (HPLC) 5MG ₹10814.18 2022-06-14 Buy

Properties

Melting point :141-142℃
Boiling point :526.3±60.0 °C(Predicted)
Density :1.566±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL
form :Yellow solid
pka :5.83±0.10(Predicted)
color :Tan
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChIKey :AXNUEXXEQGQWPA-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

FH535 is an inhibitor of β-catenin/Tcf-mediated transcription and an antagonist of ligand-dependent activation of PPARγ and PPARδ. At 15 μM, FH535 blocks the recruitment of β-catenin and GRIP1 to PPARγ and PPARδ. Presumably through these actions, FH535 is selectively toxic to some carcinoma cell lines expressing the Wnt/β-catenin pathway. FH535 is used to study the role of Wnt/β-catenin pathway in various cancer cell lines.

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