WP1066
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- ₹22910
- Product name: WP1066
- CAS: 857064-38-1
- MF: C17H14BrN3O
- MW: 356.22
- EINECS:
- MDL Number:MFCD12912450
- Synonyms:WP1066;(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide;WP1066/WP-1066;(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide;(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide WP 1066;WP1066, >=99%;wp1066(STAT Inhibitor III);Stat3 Inhibitor III, WP1066
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 10MG
- ManufacturerSigma-Aldrich(India)
- Product number573097
- Product descriptionSTAT3 Inhibitor III, WP1066 STAT3 Inhibitor III, WP1066, CAS 857064-38-1, is a cell-permeable AG490 tyrphostin analog that acts as a STAT3 pathway inhibitor. A potent anti-tumor
- Packaging10MG
- Price₹22910
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 573097 | STAT3 Inhibitor III, WP1066 STAT3 Inhibitor III, WP1066, CAS 857064-38-1, is a cell-permeable AG490 tyrphostin analog that acts as a STAT3 pathway inhibitor. A potent anti-tumor | 10MG | ₹22910 | 2022-06-14 | Buy |
Properties
Melting point :90-93oC
Boiling point :569.9±50.0 °C(Predicted)
Density :1.425
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :Off-white solid
pka :11.00±0.46(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Boiling point :569.9±50.0 °C(Predicted)
Density :1.425
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :Off-white solid
pka :11.00±0.46(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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Description
WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT3 in U87-MG and U373-MG malignant glioma cells when given at a concentration of 10 μM. It also induces apoptosis in U87-MG (IC50 = 5.6 μM) and U373-MG (IC50 = 3.7 μM) cells. WP1066 is orally bioavailable, crosses the blood-brain barrier, and demonstrates in vivo activity, including immune activation as indicated by the up-regulation of CD80 and CD86 and the induction of proliferation of effector T cells. In addition to inducing apoptosis in cancer cells, WP1066 suppresses vascular smooth muscle cell proliferation after vascular injury in mice and prevents seizures following brain injury in rats.More related product prices
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