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ChemicalBook > Product Catalogue >API >Synthetic Anti-infective Drugs >Antiviral drugs >Indinavir sulfate

Indinavir sulfate

Indinavir sulfate Structure
  • ₹0
  • Product name: Indinavir sulfate
  • CAS: 157810-81-6
  • MF: C36H49N5O8S
  • MW: 711.87
  • EINECS:682-418-9
  • MDL Number:MFCD00920346
  • Synonyms:CRIXIVAN;INDINAVIR SULFATE;INDINAVIR SULPHATE;(1(1s,2r),5(s))-2,3,5-trideoxy-n-(2,3-dihydro-2-hydroxy-1h-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-d-erythro-pentonamide sulfate;MK-639;indinavirsulfate(subjecttopatentfree) ;IDV;MK-639,Crixivan
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :150-153°C (dec)
storage temp. :-20°C Freezer
solubility :Freely soluble in water, soluble in methanol, practically insoluble in heptane.
form :Solid
color :White to Off-White
Water Solubility :>100g/L(temperature not stated)
BCS Class :2,4

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Indinavir is a protease inhibitor used as a component of highly active antiretroviral therapy to treat HIV infection and AIDS. It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM. However, indinavir demonstrates up to a 50-fold loss in potency against the HIV-1 protease drug-resistant mutations PRL24I, PRI50V, and PRG73S (Kis = 1.4, 27, and 0.55 nM).

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Suppliers and manufacturers

Hetero Drugs Limited CLEARSYNTH LABS LTD. Pharmaffiliates Analytics and Synthetics P. Ltd SynZeal Research Pvt Ltd Pharma Affiliates OCEAN TRADING CORPORATION Clinse Labs Private Limited. Medilink Pharmachem
Xiamen AmoyChem Co., Ltd
CONIER CHEM AND PHARMA LIMITED