(±)-JQ1
- ₹20080.38 - ₹81479.78
- Product name: (±)-JQ1
- CAS: 1268524-69-1
- MF: C23H25ClN4O2S
- MW: 456.99
- EINECS:
- MDL Number:MFCD23726614
- Synonyms:[(R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-6-yl]-acetic acid tert-butyl ester;tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(+/-)-SGCBD01;rac JQ-1;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester;(+/-)-JQ1;tert-butyl 2-[7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11 ,12-tetraazatricyclo[8.3.0.0,2,6]trideca-2(6),4,7,10,1 2-pentaen-9-yl]acetate
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0974
- Product description(+/-)-JQ1 ≥98% (HPLC)
- Packaging5MG
- Price₹20080.38
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0974
- Product description(+/-)-JQ1 ≥98% (HPLC)
- Packaging25MG
- Price₹81479.78
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SML0974 | (+/-)-JQ1 ≥98% (HPLC) | 5MG | ₹20080.38 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML0974 | (+/-)-JQ1 ≥98% (HPLC) | 25MG | ₹81479.78 | 2022-06-14 | Buy |
Properties
Boiling point :610.4±65.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble2mg/mL, clear (warmed)
pka :2.05±0.60(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble2mg/mL, clear (warmed)
pka :2.05±0.60(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Safety Information
Symbol(GHS): | ||||||||
---|---|---|---|---|---|---|---|---|
Signal word: | ||||||||
Hazard statements: |
|
|||||||
Precautionary statements: |
|
Description
(±) JQ1 (1268524-69-1) is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively. Competitive binding by (±) JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models establishing proof-of-concept for targeting protein-protein interactions of epigenetic readers.1 Chiral version is available for purchase (Cat#10-1584).Related product price
- Troglitazone
₹18889.63 - Adapalene
₹4000-21790.73 - 461054-93-3
₹12697.73-50379.55
Suppliers and manufacturers
Accela ChemBio Inc.
Henan Alfa Chemical Co., Ltd
Hangzhou MolCore BioPharmatech Co.,Ltd.
Nantong HI-FUTURE Biology Co., Ltd.
Aladdin Scientific
Amadis Chemical Company Limited
Energy Chemical
Chengdu Saint - Kay Biotechnology Co., Ltd.
Nanjing Shizhou Biology Technology Co.,Ltd
Taizhou Tongxin Bio-Tech Co., Ltd