KRN 633
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- Product name: KRN 633
- CAS: 286370-15-8
- MF: C20H21ClN4O4
- MW: 416.86
- EINECS:
- MDL Number:MFCD14155620
- Synonyms:KRN 633;N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propylurea;1-(2-chloro-4-(6,7-diMethoxyquinazolin-4-yloxy)phenyl)-3-propylurea;N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propylurea KRN633;VEGFR Tyrosine Kinase Inhibitor III, KRN633;KRN 633;KRN-633;CS-463;KRN633; KRN-633; KRN 633
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Properties
Melting point :231-232°C
Boiling point :545.6±50.0 °C(Predicted)
Density :1.321
storage temp. :-20°C
solubility :DMSO: soluble3mg/mL, clear (warmed)
pka :13.08±0.70(Predicted)
form :powder
color :white to beige
Boiling point :545.6±50.0 °C(Predicted)
Density :1.321
storage temp. :-20°C
solubility :DMSO: soluble3mg/mL, clear (warmed)
pka :13.08±0.70(Predicted)
form :powder
color :white to beige
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
KRN 633 is an ATP-competitive inhibitor of VEGFR kinase activity (IC50s = 170, 160, and 125 nM for VEGFR1, 2, and 3, respectively). At higher concentrations KRN 633 inhibits PDGFR-α and c-KIT with IC50 values of 0.97 and 4.3 μM, respectively, and is inactive towards a panel of 17 additional kinases. KRN 633 suppresses VEGF-dependent activation of MAPK and cell proliferation and demonstrates antitumor and antiangiogenic activity by inhibiting vessel formation and vascular permeability in human tumor xenograft models.More related product prices
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