LINDERANE
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- ₹0
- Product name: LINDERANE
- CAS: 13476-25-0
- MF: C15H16O4
- MW: 260.29
- EINECS:
- MDL Number:MFCD07781424
- Synonyms:LINDERANE;2H-10,1a-(Epoxymethano)oxireno[4,5]cyclodeca[1,2-b]furan-12-one,3,6,10,10a-tetrahydro-5,9-dimethyl-, (1aS,4E,10S,10aS)-;(1aS,4E,10S,10aS)-3,6,10,10a-Tetrahydro-5,9-dimethyl-10,1a-(epoxymethano)-2H-oxireno[4,5]cyclodeca[1,2-b]furan-12-one;(1aS,4E,10S,10aS)-3,6,10,10a-Tetrahydro-5,9-dimethyl-2H-10,1a-(epoxymethano)oxireno[4,5]cyclodeca[1,2-b]furan-12-one;LINDERANE(RG);Linderane ,98%;Linderane, 98%, from Lindera aggregata (Sims) Kosterm.;wuyaomineizhi
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Properties
Melting point :190～191℃
Boiling point :434.5±45.0 °C(Predicted)
Density :1.30±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form :Solid
color :White to Off-White
Stability :Hygroscopic
Boiling point :434.5±45.0 °C(Predicted)
Density :1.30±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form :Solid
color :White to Off-White
Stability :Hygroscopic
Safety Information
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Description
Linderane is a sesquiterpene that has been found in L. aggregata. It inhibits the cytochrome P450 (CYP) isoform CYP2C9 (Ki = 1.26 μM) in an irreversible and NADPH-dependent manner. Linderane decreases phosphoenolpyruvate carboxykinase (Pck1) and glucose-6-phosphatase (G6pc) gene expression, cAMP concentration, and CREB phosphorylation, increases phosphodiesterase 3 (PDE3) activity, and inhibits gluconeogenesis in rat primary hepatocytes. In vivo, linderane (50 mg/kg twice per day) decreases serum and hepatic triglyceride levels, as well as random-fed and fasting blood glucose levels in ob/ob mice.More related product prices
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Suppliers and manufacturers
Henan Tianfu Chemical Co.,Ltd.
Chengdu Biopurify Phytochemicals Ltd.
Chongqing Chemdad Co., Ltd
Neostar United (Changzhou) Industrial Co., Ltd.
Hefei TNJ Chemical Industry Co.,Ltd.
Apeloa Pharmaceutical Co., Ltd.
ANHUI WITOP BIOTECH CO., LTD
LEAP CHEM CO., LTD.
