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LUFFARIELLOLIDE

LUFFARIELLOLIDE Structure
  • ₹0
  • Product name: LUFFARIELLOLIDE
  • CAS: 111149-87-2
  • MF: C25H38O3
  • MW: 386.57
  • EINECS:
  • MDL Number:MFCD00211056
  • Synonyms:LUFFARIELLOLIDE;4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadienyl]-5-hydroxy-2(5H)-furanone;4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexenyl)-3,7-decadienyl]-5-hydroxyfuran-2(5H)-one;3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one;2(5H)-Furanone, 4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadien-1-yl]-5-hydroxy-
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :541.7±50.0 °C(Predicted)
Density :1.006±0.06 g/cm3(Predicted)
solubility :DMSO: soluble; Ethanol: soluble
pka :9.98±0.40(Predicted)
form :Pale yellow oil.
InChI :InChI=1S/C25H38O3/c1-18(11-7-13-21-17-23(26)28-24(21)27)9-6-10-19(2)14-15-22-20(3)12-8-16-25(22,4)5/h10-11,17,24,27H,6-9,12-16H2,1-5H3/b18-11+,19-10+
InChIKey :JPWPYTMXSXYUPG-QZPYEDBESA-N
SMILES :O1C(O)C(CC/C=C(\C)/CC/C=C(\C)/CCC2C(C)(C)CCCC=2C)=CC1=O

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Luffariellolide is a natural sesterterpenoid which reversibly inhibits secretory phospholipase A2 isoforms from bee venom (IC50 = 230 nM) and snake venom, reducing inflammation. It blocks the production of platelet-activating factor in stimulated neutrophils (IC50 = 5 μM). Luffariellolide is also a structural mimic of all-trans retinoic acid (RA) and, at 1 μM, acts as an agonist for the RA receptors RAR α, β, and γ but not for other nuclear receptors. In RA-sensitive cancer cell lines, luffariellolide induces the expression of RAR target genes and inhibits cell growth. It also inhibits the activation of hypoxia-inducible factor by hypoxia (IC50 = 3.6 μM).

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Suppliers and manufacturers

Wuhan Topule Biopharmaceutical Co., Ltd
Aladdin Scientific Olix (Shanghai) Pharmaceutical Technology Co., Ltd Wuhan Topule Shanghai Easy CDMO Co.,Ltd Cayman Chemical Company Shanghai EFE Biological Technology Co., Ltd. QUALITY CONTROL SOLUTIONS LTD. BIOMOL INTERNATIONAL, LP Alexis Corporation