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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Hormonal antineoplastic drugs >Letrozole

Letrozole

Letrozole Structure
  • ₹9926.53 - ₹42639.68
  • Product name: Letrozole
  • CAS: 112809-51-5
  • MF: C17H11N5
  • MW: 285.3
  • EINECS:675-034-8
  • MDL Number:MFCD00866241
  • Synonyms:Letrozole99%;CGS-20267, Femara;letrozolex;Lelrozol;1-[BIS(4-CYANOPHENYL)METHYL]-1,2,4-TRIAZOLE;4,4'-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile;4,4'-(1H-1,2,4-Triazole-1-ylmethylene)bisbenzonitrile;4,4'-[(1H-1,2,4-Triazole-1-yl)methylene]dibenzonitrile
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • 1G
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1540
  • Product descriptionLetrozole Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹9926.53
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberL6545
  • Product descriptionLetrozole ≥98% (HPLC)
  • Packaging10MG
  • Price₹10532.73
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberL6545
  • Product descriptionLetrozole ≥98% (HPLC)
  • Packaging50MG
  • Price₹42639.68
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) PHR1540 Letrozole Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹9926.53 2022-06-14 Buy
Sigma-Aldrich(India) L6545 Letrozole ≥98% (HPLC) 10MG ₹10532.73 2022-06-14 Buy
Sigma-Aldrich(India) L6545 Letrozole ≥98% (HPLC) 50MG ₹42639.68 2022-06-14 Buy

Properties

Melting point :181-183°C
Boiling point :563.5±60.0 °C(Predicted)
Density :1.21±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >50mg/mL
pka :1.52±0.11(Predicted)
form :White powder
color :white to off-white
Merck :14,5450
InChI :InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
InChIKey :HPJKCIUCZWXJDR-UHFFFAOYSA-N
SMILES :C(C1=CC=C(C=C1)C#N)(C1=CC=C(C=C1)C#N)N1C=NC=N1
CAS DataBase Reference :112809-51-5(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Letrozole (trade name: Femara) is an orally active nonsteroidal aromatase inhibitor. As a competitive inhibitor of the aromatase, Letrozole inhibits the conversion of androgens to estrogen (estrogen stimulates breast tissues and breast cancer reoccurrence) and gonadal steroidogenesis. It can be used for the treatment of breast cancer that is hormonally-responsive or has an unknown receptor status in postmenopausal women. Besides this, Letrozole also has some off-label use such as ovarian stimulation, pretreatment of termination of pregnancy, treatment of gynecomastia, treatment of endometriosis, and promoting spermatogenesis for male patients of nonobstructive azoospermia.

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