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Losartan Carboxaldehyde

Losartan Carboxaldehyde Structure
  • ₹0
  • Product name: Losartan Carboxaldehyde
  • CAS: 114798-36-6
  • MF: C22H21ClN6O
  • MW: 420.89
  • EINECS:
  • MDL Number:MFCD00870256
  • Synonyms:2-Butyl-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde;DUP 167;EXP 3179;Losartan Carboxaldehyde Discontinued see product # L470505;Losartan Carboxaldehyde;2-(Butyl-d3)-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde;Losartan Carboxaldehyde-d3;Losartan EP IMpurity K (LosaratnCarboxaldehyde)
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :84-86°C
Boiling point :666.7±65.0 °C(Predicted)
Density :1.34±0.1 g/cm3(Predicted)
storage temp. :Refrigerator, Under Inert Atmosphere
solubility :Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form :Solid
pka :4.16±0.10(Predicted)
color :Off-White to Light Yellow
CAS DataBase Reference :114798-36-6

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F2α . Losartan carboxaldehyde can also act as a partial agonist (EC50 = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.

More related product prices

Losartan Losartan potassium 5-[2-(4'-METHYLBIPHENYL)]TETRAZOLE 79047-41-9 Losartan Impurity D 2-Butyl-4-chloro-5-formylimidazole Triphenylmethanol 2'-[(1H-Tetrazol-5-yl)biphenyl-4-yl]Methanol

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SynThink RESEARCH CHEMICALS GLP Pharma Standards KARPSCHEM LABORATORIES Orgamine Chemicals(I) Pvt Ltd Vishrudh laboratories pvt ltd Allmpus Laboratories Pvt Ltd Pharmaffiliates Analytics and Synthetics P. Ltd SynZeal Research Pvt Ltd
Amadis Chemical Company Limited
Hangzhou FandaChem Co.,Ltd.