Losartan carboxylic acid
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- ₹6556.66 - ₹26236.34
- Product name: Losartan carboxylic acid
- CAS: 124750-92-1
- MF: C22H21ClN6O2
- MW: 436.89
- EINECS:1592732-453-0
- MDL Number:MFCD00871928
- Synonyms:AKOS 91941;2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID;’-biphenyl)-4-yl)methyl)- ;1h-imidazole-5-carboxylicacid,2-butyl-4-chloro-1-((2’-(14-tetrazol-5-yl)(1,1 ;1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxylic acid;1H-Imidazole-5-carboxylicacid, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-;2-Butyl-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylicAcid;EXP 317
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSMB01354
- Product descriptionLosartan carboxylic acid ≥95% (HPLC)
- Packaging5MG
- Price₹6556.66
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSMB01354
- Product descriptionLosartan carboxylic acid ≥95% (HPLC)
- Packaging25MG
- Price₹26236.34
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SMB01354 | Losartan carboxylic acid ≥95% (HPLC) | 5MG | ₹6556.66 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SMB01354 | Losartan carboxylic acid ≥95% (HPLC) | 25MG | ₹26236.34 | 2022-06-14 | Buy |
Properties
Melting point :130-132°C
Boiling point :707.8±70.0 °C(Predicted)
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :Inert atmosphere,2-8°C
solubility :Dimethylformamide, Dimethyl Sulfoxide, Methanol
form :Solid
pka :0.79±0.50(Predicted)
color :Light-Yellow
InChIKey :ZEUXAIYYDDCIRX-UHFFFAOYSA-N
SMILES :C1(CCCC)N(CC2=CC=C(C3=CC=CC=C3C3=NNN=N3)C=C2)C(C(O)=O)=C(Cl)N=1
Boiling point :707.8±70.0 °C(Predicted)
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :Inert atmosphere,2-8°C
solubility :Dimethylformamide, Dimethyl Sulfoxide, Methanol
form :Solid
pka :0.79±0.50(Predicted)
color :Light-Yellow
InChIKey :ZEUXAIYYDDCIRX-UHFFFAOYSA-N
SMILES :C1(CCCC)N(CC2=CC=C(C3=CC=CC=C3C3=NNN=N3)C=C2)C(C(O)=O)=C(Cl)N=1
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | |||||||||||||||||||||
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Description
Losartan is an antagonist of the angiotensin II receptor, type 1 (AT1) (Ki = 5-20 nM). It has an attenuating effect on vein graft atherosclerosis in rabbits and effectively reduces arterial blood pressure in rats. In humans, losartan controls hypertension while protecting renal function. Losartan carboxylic acid is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver. Like the parent compound, losartan carboxylic acid is a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability. Losartan, but not its metabolite, inhibits platelet aggregation in vitro.More related product prices
Losartan potassium Irbesartan Valsartan Candesartan cilexetil Ethyl acetate Trityl losartan LosartanRelated product price
- Losartan potassium
₹9103.83-22100 - Irbesartan
₹5500-38017.4 - Valsartan
₹3600-43527.33
Suppliers and manufacturers
career henan chemical co
![2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID](https://img.chemicalbook.com/ProductImageEN/2020-1/small/dd5a4f81-83bd-420f-9ace-dcb08eadd082.png)
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₹1.00 /1KG
2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID CAS:124750-92-1
2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID CAS:124750-92-1
