MK-2048
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- Product name: MK-2048
- CAS: 869901-69-9
- MF: C21H21ClFN5O4
- MW: 461.87
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- Synonyms:Pyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide, 2-[(3-chloro-4-fluorophenyl)methyl]-8-ethyl-1,2,6,7,8,9-hexahydro-10-hydroxy-N,6-dimethyl-1,9-dioxo-, (6S)-;(S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-diMethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxaMide;(6S)-2-[(3-Chloro-4-fluorophenyl)methyl]-8-ethyl-1,2,6,7,8,9-hexahydro-10-hydroxy-N,6-dimethyl-1,9-dioxopyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide;CS-1529;MK-2048 USP/EP/BP;MK-2048 MK2048
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Properties
Density :1.55
storage temp. :Store at -20°C
solubility :Soluble in DMSO > 10 mM
form :Powder
pka :6.30±0.40(Predicted)
color :Light yellow to yellow
storage temp. :Store at -20°C
solubility :Soluble in DMSO > 10 mM
form :Powder
pka :6.30±0.40(Predicted)
color :Light yellow to yellow
Safety Information
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Description
MK-2048 represents a prototype second generation integrase strand transfer inhibitor (INSTI), it was developed with the goal of retaining activity against viruses containing mutations assiciated with resistance of first-generation INSTIs, raltegravir (R100312). MK-2048 exhibits inhibitory activity towards HIV integrase and towards HIV replication. It is four times more effective in inhibiting HIV enzyme integrase than the first generation inhibitor, raltegravir.Related product price
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