ML115
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- ₹0
- Product name: ML115
- CAS: 912798-42-6
- MF: C15H15ClN2O4
- MW: 322.7436
- EINECS:
- MDL Number:MFCD09782805
- Synonyms:ML115;ML115,ML-115;3-Isoxazolecarboxamide, N-(4-chloro-2,5-dimethoxyphenyl)-5-cyclopropyl-
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Properties
Boiling point :422.9±45.0 °C(Predicted)
Density :1.389±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 25 mg/ml; DMSO: 16 mg/ml; Ethanol: 0.1 mg/ml
form :A crystalline solid
pka :9.26±0.70(Predicted)
color :White to off-white
Density :1.389±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 25 mg/ml; DMSO: 16 mg/ml; Ethanol: 0.1 mg/ml
form :A crystalline solid
pka :9.26±0.70(Predicted)
color :White to off-white
Safety Information
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| Signal word: | Warning | |||||||
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Description
Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer. ML115 is an isoxazole carboxamide that acts as a cell-permeable STAT3 activator (EC50 = 2 nM) and is more than 28,000-fold selective for STAT3 over STAT1 and NF-κB. It shows no cytotoxicity against HT-1080 or NIH-3T3 cells. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene, and enhances STAT3 activation by the pro-inflammatory cytokine IL-6. As the maintenance of pluripotency in mouse embryonic stem cells requires continued activation of STAT3, ML115 may be useful in maintaining embryonic stem cells in an undifferentiated state.More related product prices
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Suppliers and manufacturers
TargetMol Chemicals Inc.
Cayman Chemical Company
Shanghai EFE Biological Technology Co., Ltd.
Shanghai Hao Zhun Biological Technology Co., Ltd.
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
United States Biological
MedBioPharmaceutical Technology Inc
TargetMol Chemicals Inc.
Suzhou Zhixin Biotechnology Co., Ltd.
Nanjing Shizhou Biology Technology Co.,Ltd