ML355
|
- ₹0
- Product name: ML355
- CAS: 1532593-30-8
- MF: C21H19N3O4S2
- MW: 441.52
- EINECS:
- MDL Number:MFCD28167822
- Synonyms:ML355;N-2-Benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]benzenesulfonamide;ML 355;ML-355;ML355;N-(benzo[d]thiazol-2-yl)-4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide;Benzenesulfonamide, N-2-benzothiazolyl-4-[[(2-hydroxy-3-methoxyphenyl)methyl]amino]-;ML355,LOX,ML-355,Lipoxygenase,Inhibitor,inhibit,ML 355;12-LOX enzyme inhibitor;VLX 1005
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|
Properties
Melting point :>182°C (dec.)
Boiling point :654.5±65.0 °C(Predicted)
Density :1.481±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Pyridine (Very Slightly)
form :Solid
pka :7.58±0.30(Predicted)
color :Pale Beige to Beige
Boiling point :654.5±65.0 °C(Predicted)
Density :1.481±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly), Pyridine (Very Slightly)
form :Solid
pka :7.58±0.30(Predicted)
color :Pale Beige to Beige
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
Platelet-type 12-lipoxygenase (12-LO; ) catalyzes the formation of 12-HpETE from arachidonic acid . It has been found to be expressed in various tumor cells as well as pancreatic islets and can be activated by inflammatory cytokines. It has also been implicated in the modulation of hemostasis and thrombosis through its role in regulating platelet function. ML355 is a selective inhibitor of 12-LO with an IC50 value of 0.34 μM. It demonstrates greatly reduced potency for 15-LO-1, 15-LO-2, and 5-LO (IC50s = 9.7, >100, and >100 μM) and no inhibition of COX-1 and -2. In cell-based assays, ML355 has been shown to decrease calcium mobilization and thrombin receptor PAR4-induced platelet aggregation in patient-derived human platelets and to significantly inhibit arachidonic acid and calcium- ionophore-induced 12-HpETE synthesis in mouse BTC3 cells and human islets.More related product prices
VU0456810 ML364 ML277 877636-42-5 1378872-36-6 ml390 M348 ML 141 ML365 ML385 ML216 ML264 ML213 1360705-96-9 ML 161 ML-9 HYDROCHLORIDE Nodinitib-1 ML329 ML-098 ML 18Related product price
- VU0456810
₹11550.28-46558.33 - ML277
₹12394.63-50076.45 - 877636-42-5
₹11506.98-46374.3