ML 141
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- ₹12394.63 - ₹50076.45
- Product name: ML 141
- CAS: 71203-35-5
- MF: C22H21N3O3S
- MW: 407.49
- EINECS:
- MDL Number:MFCD05987165
- Synonyms:4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)benzenesulfonamide;CID-2950007;4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide ML141;4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide;ML 141;5-(4-Methoxyphenyl)-1-(4-sulfamoylphenyl)-3-phenyl-2-pyrazoline;Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem;4-[2-(1-PIPERIDINYL)ETHYL]-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZI
NE TRIHYDROCHLORIDE
3 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0407
- Product descriptionML 141 ≥98% (HPLC)
- Packaging5MG
- Price₹12394.63
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number217708
- Product descriptionCdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem The Cdc42/Rac1 GTPase Inhibitor, ML141 controls the biological activity of Cdc42/Rac1 GTPase. This small molecule/inhibitor is primarily used for Memb
- Packaging25MG
- Price₹16090
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0407
- Product descriptionML 141 ≥98% (HPLC)
- Packaging25MG
- Price₹50076.45
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0407 | ML 141 ≥98% (HPLC) | 5MG | ₹12394.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 217708 | Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem The Cdc42/Rac1 GTPase Inhibitor, ML141 controls the biological activity of Cdc42/Rac1 GTPase. This small molecule/inhibitor is primarily used for Memb | 25MG | ₹16090 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0407 | ML 141 ≥98% (HPLC) | 25MG | ₹50076.45 | 2022-06-14 | Buy |
Properties
Melting point :216 °C(Solv: ethanol (64-17-5))
Boiling point :622.9±65.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL (warmed, clear solution)
form :Yellow-white solid
pka :10.39±0.10(Predicted)
color :white to beige
Boiling point :622.9±65.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL (warmed, clear solution)
form :Yellow-white solid
pka :10.39±0.10(Predicted)
color :white to beige
Safety Information
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Description
Cdc42 is a member of the Rho GTPase subfamily that has roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking. It cycles between a GTP-bound active state and a GDP-bound inactive state. ML 141 is a noncompetitive, allosteric inhibitor of Cdc42 (EC50 = 2.1 μM) with no inhibitory action against Rho, Ras, Rab, or Rac. It also inhibits the constitutively active Cdc42 Q61L mutant (EC50 = 2.6 μM). ML 141 blocks Cdc42-dependent filopodia formation in 3T3 cells and migration of ovarian cancer cells, prevents Cdc42-regulated virus infection, and inhibits the signaling pathway of VLA-4 integrin. It is a useful tool to interrogate the role of Cdc42 intracellular signaling and cell activity.More related product prices
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