RG108
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- ₹11800 - ₹22256.2
- Product name: RG108
- CAS: 48208-26-0
- MF: C19H14N2O4
- MW: 334.33
- EINECS:
- MDL Number:MFCD08705332
- Synonyms:(S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid;RG108/RG-108;(S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid;N-Phthaloyl-L-tryptophan;1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, (αS)-;N-Phthaloyl-L-tryptophan (S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid;DNA Methyltransferase Inhibitor;N-Phthalyl-L-tryptophan
3 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 10MG
- 50MG
- 200MG
- ManufacturerTCI Chemicals (India)
- Product numberP2023
- Product descriptionN-Phthalyl-L-tryptophan
- Packaging50MG
- Price₹11800
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberP2023
- Product descriptionN-Phthalyl-L-tryptophan
- Packaging200MG
- Price₹12000
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberR8279
- Product descriptionRG108 ≥98% (HPLC), powder
- Packaging10MG
- Price₹22256.2
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | P2023 | N-Phthalyl-L-tryptophan | 50MG | ₹11800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P2023 | N-Phthalyl-L-tryptophan | 200MG | ₹12000 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | R8279 | RG108 ≥98% (HPLC), powder | 10MG | ₹22256.2 | 2022-06-14 | Buy |
Properties
Melting point :192-194℃
Boiling point :606.0±50.0 °C(Predicted)
Density :1.502±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: >10mg/mL
pka :3.62±0.10(Predicted)
form :powder
color :yellow
Sensitive :Light Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
CAS DataBase Reference :48208-26-0
Boiling point :606.0±50.0 °C(Predicted)
Density :1.502±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: >10mg/mL
pka :3.62±0.10(Predicted)
form :powder
color :yellow
Sensitive :Light Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
CAS DataBase Reference :48208-26-0
Safety Information
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Description
DNA methylation regulates gene expression in normal and malignant cells. RG-108 is a non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM in vitro). It significantly reduces the methylation of genomic DNA in cells at 10 μM without detectable toxicity, distinguishing it from nucleoside-based inhibitors like 5-azacytidine. Further, RG-108 inhibits DNA methyltransferase activity by blocking the enzyme active site. Through these actions, RG-108 demethylates and reactivates epigenetically silenced tumor suppressor genes.Related product price
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