5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one
![5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one Structure](/CAS/20200119/GIF/877636-42-5.gif)
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- ₹11506.98 - ₹46374.3
- Product name: 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one
- CAS: 877636-42-5
- MF: C17H11N3O6S
- MW: 385.35
- EINECS:
- MDL Number:
- Synonyms:5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one;ML221;ML221; ML 221; ML-221;CS-2842;ML 221;ML-221;4H-Pyran-4-one, 5-[(4-nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-;ML221 >=98% (HPLC);4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0919
- Product descriptionML221 ≥98% (HPLC)
- Packaging5MG
- Price₹11506.98
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0919
- Product descriptionML221 ≥98% (HPLC)
- Packaging25MG
- Price₹46374.3
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0919 | ML221 ≥98% (HPLC) | 5MG | ₹11506.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0919 | ML221 ≥98% (HPLC) | 25MG | ₹46374.3 | 2022-06-14 | Buy |
Properties
Boiling point :624.1±55.0 °C(Predicted)
Density :1.54±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :0.30±0.33(Predicted)
form :powder
color :white to beige
Density :1.54±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :0.30±0.33(Predicted)
form :powder
color :white to beige
Safety Information
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Description
ML-221 is an antagonist of the G protein-coupled receptor (GPCR) APJ (IC50 = 4.8 μM). It is selective for APJ over the angiotensin II type 1 (AT1) receptor (IC50 = >78 μM). ML-221 antagonizes apelin 13-induced activation of APJ in cAMP and β-arrestin recruitment assays (IC50s = 0.7 and 1.75 μM, respectively). It inhibits proliferation and angiogenesis in Mz-ChA-1 cholangiocarcinoma cells when used at concentrations ranging from 5 to 15 μM. In vivo, ML-221 (150 μg/kg) reduces tumor growth in a Mz-ChA-1 mouse xenograft model. Intrathecal injection of ML-221 (10 μg per animal) reduces mechanical allodynia and heat hyperalgesia induced by chronic constriction injury (CCI) of the sciatic nerve in rats. ML-221 also inhibits pathological angiogenesis and enhances normal vessel recovery in retinal ischemic regions in a mouse model of oxygen-induced retinopathy.Related product price
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Suppliers and manufacturers
career henan chemical co
![5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one](https://img.chemicalbook.com/ProductImageEN/2020-1/small/666cff23-51c7-49f5-a336-a34eda87aa4b.png)
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₹9.80 /1.79999995231628KG
5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one CAS:877636-42-5
5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one CAS:877636-42-5