ML-228
- ₹0
- Product name: ML-228
- CAS: 1357171-62-0
- MF: C27H21N5
- MW: 415.49
- EINECS:
- MDL Number:MFCD26792570
- Synonyms:ML-228;N-([1,1-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine;ML228; ML 228;N-([1,1'Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine;CID-46742353;ML-228;CID-46742353;L-228;1,2,4-Triazin-5-amine, N-([1,1'-biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-
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Properties
Boiling point :686.0±65.0 °C(Predicted)
Density :1.228±0.06 g/cm3(Predicted)
storage temp. :-20°C, Inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :2.03±0.63(Predicted)
color :Pale Yellow to Light Yellow
Density :1.228±0.06 g/cm3(Predicted)
storage temp. :-20°C, Inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :2.03±0.63(Predicted)
color :Pale Yellow to Light Yellow
Safety Information
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Description
The hypoxia-inducible factor (HIF) transcription factors are members of the basic-helix-loop-helix (bHLH) family of transcription factors and play important roles in maintaining cellular oxygen homeostasis. HIF-1α has emerged as an important drug target in breast and prostate cancer, cardiovascular disease, and ischemia. ML-228 is an activator of the HIF signaling pathway, as demonstrated by HIF response element (HRE) reporter assay (EC50 = 1.2 μM), HIF-1α nuclear translocation assay (EC50 = 1.3 μM), and increased VEGF expression (EC50 = 1.6 μM). Its activity in the HRE assay is blocked by excess iron, suggesting that ML-228 can chelate iron. Molecular modeling indicates that ML-228 does not modulate HIF signaling by binding to prolyl hydroxyases. ML-228 also significantly inhibits ligand binding to several channels, receptors, and transporters, including ERG potassium channel, 5-HT2B and A3 adenosine receptors, and dopamine transporter.Related product price
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