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ChemicalBook > Product Catalogue >API >Nervous system drugs >Other nervous system drugs >Midazolam

Midazolam

Midazolam Structure
  • ₹0
  • Product name: Midazolam
  • CAS: 59467-70-8
  • MF: C18H13ClFN3
  • MW: 325.77
  • EINECS:261-774-5
  • MDL Number:MFCD08272801
  • Synonyms:8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-α][1,4]benzodiazepine;Midazolam;MIDAZOLAM-D4 MALEATE;8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine;Midazolam (base and/or unspecified salts) ;MidazolamBaseE.P;4H-Imidazo1,5-a1,4benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl-;MIDAZOLAM,BP,EP
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :161-164°C
Boiling point :496.9±55.0 °C(Predicted)
Density :1.3136 (estimate)
Flash point :9 °C
storage temp. :Controlled Substance, -20°C Freezer
solubility :Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent), soluble in methanol.
form :Solid:crystalline
pka :pKa 1.7±0.1;6.15± 0.1 (Uncertain)
Water Solubility :54mg/L(24 ºC)
BCS Class :1
LogP :2.73
CAS DataBase Reference :59467-70-8(CAS DataBase Reference)
NIST Chemistry Reference :Midazolam(59467-70-8)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Midazolam is the most commonly used parenteral sedative in anaesthetic practice. The structure of midazolam is altered by local changes in pH (tautomerism), and the two different forms confer either water or lipid solubility to the drug . At pH<4 the benzodiazepine nucleus opens because of an ionisable amine group in the molecule's structure, and this increases water solubility. At plasma pH the amine group is incorporated back into the unionised ring form of the molecule, which is highly lipid soluble and diffuses rapidly into the brain. A concentrated preparation (5mgml ?1 ) is available for i.m. injection and absorption is rapid compared with diazepam.

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