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NADA

NADA Structure
  • ₹0
  • Product name: NADA
  • CAS: 199875-69-9
  • MF: C28H41NO3
  • MW: 439.63
  • EINECS:
  • MDL Number:MFCD03412031
  • Synonyms:ARACHIDONOYLDOPAMIDE;ARACHIDONOYL DOPAMINE;AA-DA;NADA;N-ARACHIDONOYL-3-HYDROXYTYRAMINE;N-ARACHIDONOYLDOPAMINE;N-[2-(3,4-DIHYDROXYPHENYL)ETHYL]-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE;N-(3,4-Dihydroxyphenethyl)acetamide
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :640.0±55.0 °C(Predicted)
Density :1.023±0.06 g/cm3(Predicted)
Flash point :14 °C
storage temp. :−20°C
solubility :Soluble in DMSO (up to 50 mg/ml).
pka :9.79±0.10(Predicted)
form :ethanol solution
color :Pale yellow
Sensitive :Air Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Subject to air oxidation Solutions in DMSO may be stored at -80° under an inert atmosphere for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Several different arachidonoyl amino acids, including N-arachidonoyl dopamine (NADA), have been isolated and characterized from bovine brain. NADA is the amide of the neurotransmitter dopamine and arachidonic acid. NADA is a CB1-selective agonist, inducing the typical tetrad of hypothermia, analgesia, catalepsy, and hypomotility in rats which exceeds that of anandamide (AEA). NADA is a full agonist at the vanilloid receptor 1, but is inactive on the dopaminergic D1 and D2 receptors. NADA is also a potent inhibitor (IC50 = 0.25 μM) of the proliferation of MCF-7 breast carcinoma cells. Recent reports of NADA’s endothelium-dependent vasodilation indicate that some of its cannabinergic activities antagonized by SR141716A may be non-CB1/CB2 dependent.

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