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NS-2028

NS-2028 Structure
  • ₹26600.01 - ₹104850.95
  • Product name: NS-2028
  • CAS: 204326-43-2
  • MF: C9H5BrN2O3
  • MW: 269.05
  • EINECS:
  • MDL Number:MFCD01530052
  • Synonyms:NS-2028;8-BROMO-4H-2,5-DIOXA-3,9B-DIAZA CYCLOPENTA[A]NAPHTHALEN-1-ONE;4H-8-BROMO-1,2,4-OXADIAZOLO(3,4-D)BENZ(B)(1,4)OXAZIN-1-ONE;4H-8-BROMO-1,2,4-OXADIAZOLO(3,4-D)BENZO(B)(1,4)OXAZIN-1-ONE;4-H-BROMO-1,2,4-OXADIAZOLE(3,4-ALPHA)BENZ(B)OXAZIN-1-ONE;NS 2028 - CAS 204326-43-2 - Calbiochem;8-Bromo-1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]Benzoxazin-1-One;8-bromo-4~{H}-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product number492030
  • Product descriptionNS 2028 - CAS 204326-43-2 - Calbiochem Potent, specific, and irreversible inhibitor of soluble guanylyl cyclase.
  • Packaging5MG
  • Price₹26600.01
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberN211
  • Product descriptionNS 2028 solid
  • Packaging5MG
  • Price₹26802.7
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberN211
  • Product descriptionNS 2028 solid
  • Packaging25MG
  • Price₹104850.95
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 492030 NS 2028 - CAS 204326-43-2 - Calbiochem Potent, specific, and irreversible inhibitor of soluble guanylyl cyclase. 5MG ₹26600.01 2022-06-14 Buy
Sigma-Aldrich(India) N211 NS 2028 solid 5MG ₹26802.7 2022-06-14 Buy
Sigma-Aldrich(India) N211 NS 2028 solid 25MG ₹104850.95 2022-06-14 Buy

Properties

Melting point :160~170℃
Boiling point :353.8±52.0 °C(Predicted)
Density :2.06±0.1 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :DMSO: 13 mg/mL
pka :-1.18±0.20(Predicted)
form :solid
color :white

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

NS-2028 is a specific inhibitor of soluble guanylyl cyclase. It inhibits purified bovine lung guanylyl cyclase in a concentration dependent and irreversible manner with IC50 values of 30 and 200 nM for basal and NO-stimulated enzymes, respectively. S-nitroso-glutathione-enhanced guanylyl cyclase activity in mouse cerebellum homogenates is inhibited by NS-2028 with an IC50 value of 17 nM, making it about 4.7 fold more potent than ODQ, which has an IC50 value of 80 nM for inhibition of soluble guanylyl cyclase in the same assay. NS-2028 does not inhibit particulate guanylyl cyclase or adenylyl cyclase.

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