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YC-1

YC-1 Structure
  • ₹20080.38 - ₹71878
  • Product name: YC-1
  • CAS: 170632-47-0
  • MF: C19H16N2O2
  • MW: 304.34
  • EINECS:
  • MDL Number:MFCD06407798
  • Synonyms:2-Furanmethanol, 5-[1-(phenylmethyl)-1H-indazol-3-yl]-;Nsc728165;(5-(1-Benzyl-1H-indazol-3-yl)furan-2-yl)Methanol;YC 1 (pharMaceutical);1-Benzyl-3-(5-hydroxymethylfur-2-yl)indazole;1-benzyl-3-(5-hydroxymethyl-furan-2-yl)indazole;Lificiguat(YC-1);5-[1-(PHENYLMETHYL)-1H-INDAZOL-3-YL]-2-FURANMETHANOL
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberY102
  • Product descriptionYC-1 powder
  • Packaging5MG
  • Price₹20080.38
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number688100
  • Product descriptionYC-1 - CAS 170632-47-0 - Calbiochem A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase.
  • Packaging5MG
  • Price₹23550
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberY102
  • Product descriptionYC-1 powder
  • Packaging25MG
  • Price₹71878
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) Y102 YC-1 powder 5MG ₹20080.38 2022-06-14 Buy
Sigma-Aldrich(India) 688100 YC-1 - CAS 170632-47-0 - Calbiochem A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase. 5MG ₹23550 2022-06-14 Buy
Sigma-Aldrich(India) Y102 YC-1 powder 25MG ₹71878 2022-06-14 Buy

Properties

Melting point :110-112℃
Boiling point :522.2±50.0 °C(Predicted)
Density :1.24±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :DMSO: 12 mg/mL
pka :13.83±0.10(Predicted)
form :solid
color :white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase. It inhibits collagen (10 μg/ml) and thrombin (0.1 U/ml) induced platelet aggregation with IC50 values of 11.7-14.6 and 57.3-59.3 μM, respectively. In the absence of NO or carbon monoxide (CO), 200 μM YC-1 increases the activity of purified soluble guanylyl cyclase 12-fold, with an ED50 value of 20 μM. At a concentration of 200 μM, YC-1 potentiates the maximal activity of soluble guanylyl cyclase in the presence of NO or CO by 40% and >3,000%, respectively.

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