Nelarabine
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- ₹17600
- Product name: Nelarabine
- CAS: 121032-29-9
- MF: C11H15N5O5
- MW: 297.27
- EINECS:642-916-9
- MDL Number:MFCD00871078
- Synonyms:(2R,3S,4S,5R)-2-(2-AMino-6-Methoxy-9H-purin-9-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol;506U78;(2R,3S,4R,5R)-2-(2-amino-6-methoxy-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol;2-amino-9-β-D-arabinofuranosyl-6-methoxy-9H-purine;NELARABINE;Nelzarabine [USAN];9beta-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine;Nelarabine (Arranon)
1 prices
Selected condition：
Brand
- TCI Chemicals (India)
Package
- 100MG
- ManufacturerTCI Chemicals (India)
- Product numberN1144
- Product descriptionNelarabine
- Packaging100MG
- Price₹17600
- Updated2022-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | N1144 | Nelarabine | 100MG | ₹17600 | 2022-05-26 | Buy |
Properties
Melting point :209-217°
alpha :D20 +55.9° (c = 0.27 in DMF)
Boiling point :721.0±70.0 °C(Predicted)
Density :1.98±0.1 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
solubility :DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly, Sonicated)
form :Solid
pka :13.07±0.70(Predicted)
color :White
InChI :InChI=1/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/s3
InChIKey :IXOXBSCIXZEQEQ-GCTRTDOSNA-N
SMILES :N1(C=NC2C(OC)=NC(N)=NC1=2)[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 |&1:12,13,15,17,r|
CAS DataBase Reference :121032-29-9(CAS DataBase Reference)
alpha :D20 +55.9° (c = 0.27 in DMF)
Boiling point :721.0±70.0 °C(Predicted)
Density :1.98±0.1 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
solubility :DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly, Sonicated)
form :Solid
pka :13.07±0.70(Predicted)
color :White
InChI :InChI=1/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/s3
InChIKey :IXOXBSCIXZEQEQ-GCTRTDOSNA-N
SMILES :N1(C=NC2C(OC)=NC(N)=NC1=2)[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 |&1:12,13,15,17,r|
CAS DataBase Reference :121032-29-9(CAS DataBase Reference)
Safety Information
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Description
Nelarabine is a new member of the purine nucleoside antimetabolite class of drugs. It was launched as an intravenous infusion for treating relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) after at least two prior chemotherapy regimens. Nelarabine is a pro-drug of 9-b-D-arabinofuranosylguanine (ara-G), a deoxyguanosine derivative with a high level of T-cell selective cytotoxicity. Although Ara-G has been known since the 1960s, it has not been used in clinical studies due to its poor solubility. Nelarabine is the O-methyl derivative of ara-G with approximately 10 times greater aqueous solubility. It is demethylated in vivo by adenosine deaminase to produce ara-G, which is subsequently converted to the active 5’-triphosphate, ara-GTP. Accumulation of ara-GTP in leukemic blasts allows for incorporation into DNA, leading to inhibition of DNA synthesis and cell death.Related product price
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