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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Apoptosis >Mdm2 antagonists >Nutlin-3b

Nutlin-3b

Nutlin-3b Structure
  • ₹0
  • Product name: Nutlin-3b
  • CAS: 675576-97-3
  • MF: C30H30Cl2N4O4
  • MW: 581.49
  • EINECS:
  • MDL Number:MFCD11977784
  • Synonyms:Nutlin-3b;4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone;2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-;4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone Nutlin 3b;NUTLIN-3B;NUTLIN 3B;4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imid;CS-986;4-((4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Density :1.36
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥55.5 mg/mL in EtOH; ≥57.25 mg/mL in DMSO
form :crystalline solid
pka :14.35±0.20(Predicted)
color :Off-white to yellow

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P273 Avoid release to the environment.
P501 Dispose of contents/container to..…

Description

(+)-Nutlin-3 is the enantiomer and less active form of the p53-Mdm2 protein-protein interaction inhibitor (–)-nutlin-3 . It inhibits the interaction between p53 and Mdm2 150-fold less potently than (–)-nutlin-3 with an IC50 value of 13.6 μM. (+)-Nutlin-3 has been used as a negative control for the p53-modulating activity of (–)-nutlin-3 in cancer cells.

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Suppliers and manufacturers

career henan chemical co
Nutlin-3b
₹1.00 /1g
Nutlin-3b CAS:675576-97-3
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
Wuhan Topule Biopharmaceutical Co., Ltd
LEAPCHEM CO., LTD.
Aladdin Scientific