Obatoclax mesilate
|
- ₹0
- Product name: Obatoclax mesilate
- CAS: 803712-79-0
- MF: C20H19N3O.CH4O3S
- MW: 413.49
- EINECS:804-325-6
- MDL Number:MFCD18074508
- Synonyms:OBATOCLAX MESYLATE;2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate;Obatoclax mesilate;1H-Indole, 2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-, monomethanesulfonate;Gx 15-070;Gx 15-070ms;Gx015-070;Unii-39200fj43j
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|
Properties
storage temp. :-20°C
solubility :Soluble in DMSO (up to 5 mg/ml).
form :solid
color :Purple
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
solubility :Soluble in DMSO (up to 5 mg/ml).
form :solid
color :Purple
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
| Symbol(GHS): |
|
||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Danger | ||||||||||||||||||||||||
| Hazard statements: |
|
||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Obatoclax is an antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd = ~500 nM). It prevents the interaction of these pro-survival proteins with Bax or Bak, thereby inducing apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3. Obstoclax also induces autophagy in mouse embryo fibroblasts and in HeLa cells. This compound inhibits the growth of cancer cell lines and primary cancer isolates.Related product price
- 2-Methoxyethanol
₹530-42451 - Methanesulfonic acid
₹370-58430 - Pyrrole
₹900-108498.98
