PCI 34051
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- ₹0
- Product name: PCI 34051
- CAS: 950762-95-5
- MF: C17H16N2O3
- MW: 296.32
- EINECS:
- MDL Number:MFCD11114393
- Synonyms:N-hydroxy-1-(4-Methoxybenzyl)-1H-indole-6-carboxaMide;PCI 34051;PCI-34051;1-(4-methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide;1H-Indole-6-carboxamide, N-hydroxy-1-[(4-methoxyphenyl)methyl]-;N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide;PCI-34051;PCI 34051;N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide
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Properties
Density :1.25
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥14.8 mg/mL in DMSO
form :Powder
pka :9.16±0.30(Predicted)
color :White to gray
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥14.8 mg/mL in DMSO
form :Powder
pka :9.16±0.30(Predicted)
color :White to gray
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
PCI 34051 is a potent histone deacetylase (HDAC) 8 inhibitor (IC50 = 0.01 μM) with >200-fold selectivity over HDAC isoforms 1, 2, 3, 6, and 10 (IC50s = 4, >50, >50, 2.9, and 13 μM, respectively). PCI 34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias (GI50s = 2.4 - 4 μM), but not in other hematopoietic or solid tumor lines. This compound has also been used to support a critical role for HDAC8 in the coordinated deacetylation of the core cohesion component SMC3 during mitosis.More related product prices
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![N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide](https://img.chemicalbook.com/ProductImageEN/2019-12/small/6fe7ce67-2ff7-463f-8bd4-313145366791.png){kind=small}