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PD158780

PD158780 Structure
  • ₹5600 - ₹20250
  • Product name: PD158780
  • CAS: 171179-06-9
  • MF: C14H12BrN5
  • MW: 330.18
  • EINECS:
  • MDL Number:MFCD00942160
  • Synonyms:N4-(3-Bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine;Pyrido[3,4-d]pyriMidine-4,6-diaMine,N4-(3-broMophenyl)-N6-Methyl- (Related Reference);Pyrido[3,4-d]pyriMidine-4,6-diaMine,N4-(3-broMophenyl)-N6-Methyl-;PD 158780 solution;InSolution? PD 158780 ;PD 158780 - CAS 171179-06-9 - Calbiochem;InSolution PD 158780 - CAS 171179-06-9 - Calbiochem;PD 158780; PD-158780
4 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 500μG
  • 10MG
  • 50MG
  • ManufacturerTCI Chemicals (India)
  • Product numberP2567
  • Product descriptionPD 158780
  • Packaging10MG
  • Price₹5600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberP2567
  • Product descriptionPD 158780
  • Packaging50MG
  • Price₹16900
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number513035
  • Product descriptionPD 158780 - CAS 171179-06-9 - Calbiochem A potent, cell-permeable, reversible, ATP-competitive inhibitor of the EGFR tyrosine kinase activity (IC?? = 8 pM).
  • Packaging500μG
  • Price₹20250
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number513036
  • Product descriptionInSolution PD 158780 - CAS 171179-06-9 - Calbiochem
  • Packaging500μG
  • Price₹20250
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) P2567 PD 158780 10MG ₹5600 2022-05-26 Buy
TCI Chemicals (India) P2567 PD 158780 50MG ₹16900 2022-05-26 Buy
Sigma-Aldrich(India) 513035 PD 158780 - CAS 171179-06-9 - Calbiochem A potent, cell-permeable, reversible, ATP-competitive inhibitor of the EGFR tyrosine kinase activity (IC?? = 8 pM). 500μG ₹20250 2022-06-14 Buy
Sigma-Aldrich(India) 513036 InSolution PD 158780 - CAS 171179-06-9 - Calbiochem 500μG ₹20250 2022-06-14 Buy

Properties

Melting point :174.0 to 178.0 °C
Boiling point :499.6±45.0 °C(Predicted)
Density :1.611±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO: ≥20mg/mL
form :Yellow solid
pka :5.80±0.30(Predicted)
color :yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

PD 158780 is a pyridopyrimidine derivative that reversibly inhibits auto and transphosphorylation of all four members of the ErbB receptor tyrosine kinase superfamily: EGFR (IC50 = 8 μM), ErbB2 (IC50 = 49 nM), ErbB3, and ErbB4 (IC50 = 52 nM). It does not inhibit PDGF or FGF-mediated tyrosine phosphorylation. At 0.5 μM, PD 158780 has been shown to induce G1 cell cycle arrest in MCF10A breast cancer cells.

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